Evidence map›Paper›PMID 24857950›Full record

ArticlePloS one2014

FBI-1 enhances ETS-1 signaling activity and promotes proliferation of human colorectal carcinoma cells.

Min Zhu, Mingyang Li, Fan Zhang, Fan Feng, Weihao Chen, Yutao Yang, Jiajun Cui, Dong Zhang, Enqiang Linghu

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. The Roles of Zinc Finger Proteins in Colorectal Cancer.International journal of molecular sciences · 2023
    Review
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  8. Review
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  11. FBI-1 mRNA in normal mucosa is an independent prognostic factor in colorectal cancer patients.International journal of clinical and experimental pathology · 2018
    Article
  12. Article
  13. Article
  14. MicroRNA-137 represses FBI-1 to inhibit proliferation and in vitro invasion and migration of hepatocellular carcinoma cells.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016
    Article
  15. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Min ZhuDepartment of oncology, Nan Lou Division, Chinese PLA General Hospital, Beijing, P. R. China.
Mingyang LiDepartment of Gastroenterology, Nan Lou Division, Chinese PLA General Hospital, Beijing, P. R. China.
Fan ZhangTumor Center, Chinese PLA General Hospital, Beijing, P. R. China.
Fan FengDepartment of Pharmacy, General Hospital of Shenyang Military Command, Shenyang, P. R. China.
Weihao ChenDepartment of Urology, Chinese PLA General Hospital, Beijing, P. R. China.
Yutao YangBeijing Institute for Neuroscience, Capital Medical University, Beijing, P. R. China.
Jiajun CuiDepartment of Cancer and cell Biology, College of Medicine, University of Cincinnati, Cincinnati, Ohio, United States of America.
Dong ZhangDepartment of oncology, Nan Lou Division, Chinese PLA General Hospital, Beijing, P. R. China.
Enqiang LinghuDepartment of Gastroenterology, Chinese PLA General Hospital, Beijing, P. R. China.
Chinese PLA General Hospital · CNCapital Medical University · CNGeneral Hospital of Shenyang Military Region · CNUniversity of Cincinnati · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, we investigated a potential regulatory role of FBI-1 in transcription factor activity of ETS-1. The protein interaction was identified between ETS-1 and FBI-1 in lovo cells. The accumulating data showed that FBI-1 promoted the recruitment of ETS-1 to endogenous promoter of its target genes and increase ETS-1 accumulation in the nuclear. Our work also indicated that the FBI-1 enhances ETS-1 transcription factor activity via down-regulating p53-mediated inhibition on ETS-1. Further, FBI-1 plays a role in regulation of colorectal carcinoma cells proliferation. These findings supported that FBI-1 might be a potential molecule target for treating colorectal carcinoma.

Indexed as

Signal TransductionActive Transport, Cell NucleusCell Line, TumorCell NucleusCell ProliferationColorectal NeoplasmsDNA-Binding ProteinsGene Expression Regulation, NeoplasticGene Knockdown TechniquesHumansMatrix Metalloproteinase 1Neoplasm InvasivenessPromoter Regions, GeneticProto-Oncogene Protein c-ets-1Transcription FactorsTranscription, GeneticDNA-Binding ProteinsMatrix Metalloproteinase 1MMP1 protein, humanProto-Oncogene Protein c-ets-1Transcription FactorsTumor Suppressor Protein p53ZBTB7A protein, human

Identifiers

PMID24857950
PMCPMC4032333
OpenAlexW1964735161

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.