Evidence map›Paper›PMID 24857150›Full record

ReviewAmerican Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting2014

Prevention of prostate cancer: outcomes of clinical trials and future opportunities.

Ian Thompson, Alan Kristal, Elizabeth A Platz

Open access · bronzeAbstract readReview
In one paragraph

Review in American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
  2. Observational
  3. Challenges to and considerations of designing cancer prevention trials.Journal of the National Cancer Institute. Monographs · 2025
    Article
  4. Review
  5. A Competition between Hydrogen, Stacking, and Halogen Bonding inInternational journal of molecular sciences · 2022
    Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Ian ThompsonFrom the Cancer Therapy and Research Center, University of Texas HSC at San Antonio, San Antonio, TX; Fred Hutchinson Cancer Research Center, Seattle, WA; and Johns Hopkins Bloomberg School of Public Health and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD.
Alan KristalFrom the Cancer Therapy and Research Center, University of Texas HSC at San Antonio, San Antonio, TX; Fred Hutchinson Cancer Research Center, Seattle, WA; and Johns Hopkins Bloomberg School of Public Health and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD.
Elizabeth A PlatzFrom the Cancer Therapy and Research Center, University of Texas HSC at San Antonio, San Antonio, TX; Fred Hutchinson Cancer Research Center, Seattle, WA; and Johns Hopkins Bloomberg School of Public Health and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD.
Cancer Research Center · USFred Hutch Cancer Center · USSidney Kimmel Comprehensive Cancer Center · US

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI WILLIAM George NELSON · 1985 to 2026
$208.6M
SWOG Foreign AccrualsU10CA037429 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BLANKE, CHARLES D., MEYSKENS, FRANK L. · 1985 to 2014
$205.2M
TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Robin Jean Leach · 1991 to 2026
$59.1M
SAN ANTONIO CENTER OF BIOMARKERS OF RISK FOR PROSTATE CAU01CA086402 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI LEACH, ROBIN JEAN, THOMPSON, IAN M. · 2000 to 2018
$33.1M
Oxidative Damage and DNA Repair in the PCPTP01CA108964 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LIPPMAN, SCOTT M · 2005 to 2009
$13.6M
NCI NIH HHS CA37429NCI NIH HHS P01 CA108964NCI NIH HHS P30 CA006973NCI NIH HHS P30 CA054174NCI NIH HHS U01 CA086402NCI NIH HHS U01 CA86402NCI NIH HHS U10 CA037429
6 · The paper itself

Abstract

Prostate cancer is an excellent target for prevention, to reduce both mortality and the burden of overdetection of potential inconsequential disease whose diagnosis increases cost, morbidity, and anxiety. The Prostate Cancer Prevention Trial has demonstrated that finasteride significantly reduces the risk of prostate cancer but only low-grade disease; overall survival is unaffected. In the Selenium and Vitamin E Cancer Prevention Trial (SELECT) clinical trial, selenium had no effect on prostate cancer risk, but alpha tocopherol significantly increased the risk by 17%. The most promising future approaches to prostate cancer prevention will likely focus on nutrition, especially weight control, and through modulation of inflammation.

Indexed as

Clinical Trials as TopicClinical Trials, Phase III as TopicFinasterideHumansInflammationMaleMiddle AgedProstatic NeoplasmsSeleniumTreatment OutcomeVitamin EFinasterideSeleniumVitamin E

Identifiers

PMID24857150
PMCPMC4322917
OpenAlexW1984962115

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.