ArticleBMB reports2014
Zinc finger and BTB domain-containing protein 3 is essential for the growth of cancer cells.
Article in BMB reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 28 citations in OpenAlex.
- Trial
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- Challenges and opportunities for the diverse substrates of SPOP E3 ubiquitin ligase in cancer.Theranostics · 2025Review
- SMCHD1 activates the expression of genes required for the expansion of human myoblasts.Nucleic acids research · 2024Article
- Cellular origin and molecular mechanisms of lung metastases in patients with aggressive hepatoblastoma.Hepatology communications · 2024Article
- BTB protein family and human breast cancer: signaling pathways and clinical progress.Journal of cancer research and clinical oncology · 2023Review
- Transcription Factor Zbtb20 as a Regulator of Malignancy and Its Practical Applications.International journal of molecular sciences · 2023Review
- An autoimmune pleiotropic SNP modulates IRF5 alternative promoter usage through ZBTB3-mediated chromatin looping.Nature communications · 2023Article
- Effect of inhaled anaesthetics gases on cytokines and oxidative stress alterations for the staff health status in hospitals.International archives of occupational and environmental health · 2021Article
- Novel functional proteins coded by the human genome discovered in metastases of melanoma patients.Cell biology and toxicology · 2020Article
- The Dynamic Chromatin Architecture of the Regenerating Liver.Cellular and molecular gastroenterology and hepatology · 2020Article
- Genetic variants in glutamine metabolic pathway genes predict cutaneous melanoma-specific survival.Molecular carcinogenesis · 2019Article
- SPOP targets oncogenic protein ZBTB3 for destruction to suppress endometrial cancer.American journal of cancer research · 2019Article
- Article
- Genome-wide identification and expression analysis of the BTB domain-containing protein gene family in tomato.Genes & genomics · 2018Article
- The macro-evolutionary events in esophageal squamous cell carcinoma.Oncotarget · 2017Article
- Nutrient restriction of glucose or serum results in similar proteomic expression changes in 3D colon cancer cell cultures.Nutrition research (New York, N.Y.) · 2016Article
- Dnmt3a regulates myeloproliferation and liver-specific expansion of hematopoietic stem and progenitor cells.Leukemia · 2016Article
- The effect of baicalin in a mouse model of retinopathy of prematurity.BMB reports · 2015Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ZBTB3 belongs to the Zinc finger and BTB/POZ domain containing transcription factor family; however, its biological role has rarely been studied. We demonstrate for the first time, to our knowledge, that ZBTB3 is an essential factor for cancer cell growth via the regulation of the ROS detoxification pathway. Suppression of ZBTB3 using two different short hairpin RNAs in human melanoma, lung carcinoma, and breast carcinoma results in diminished cell growth. In addition, we found that suppression of ZBTB3 activates a caspase cascade, including caspase-9, -3, and PARP leading to cellular apoptosis, resulting from failed ROS detoxification. We identified that ZBTB3 plays an important role in the gene expression of ROS detoxification enzymes. Our results reveal that ZBTB3 may play a critical role in cancer cell growth via the ROS detoxification system. Therefore, therapeutic strategies that target ZBTB3 could be used in selective cancer treatments.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.