ArticleCell reports2014
Limitations of preimplantation genetic diagnosis for mitochondrial DNA diseases.
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In one paragraph
Article in Cell reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Successful live birth after preimplantation genetic testing for combined nuclear RNASEH2C and mitochondrial MT-TL1 variants.Journal of assisted reproduction and genetics · 2026Article
- Concordant mtDNA heteroplasmy between trophectoderm and inner cell mass supports blastocyst-stage PGT-mt for m.14487T>C.Journal of assisted reproduction and genetics · 2026Article
- Current state of the art in the transmission of mitochondrial DNA pathogenic variants: reviewing preventive-therapeutic alternatives.Journal of assisted reproduction and genetics · 2026Review
- Colorectal Adenocarcinoma: A Comprehensive Narrative Review of Molecular Pathogenesis, Metabolic Vulnerabilities, and Therapeutic Potential of Sorghum Polyphenols.Analytical cellular pathology (Amsterdam) · 2026Review
- Causes of and Solutions to Mitochondrial Disorders: A Literature Review.International journal of molecular sciences · 2025Review
- Genetic testing for mitochondrial disease: the United Kingdom best practice guidelines.European journal of human genetics : EJHG · 2023Article
- Mitochondrial Inheritance Following Nuclear Transfer: From Cloned Animals to Patients with Mitochondrial Disease.Methods in molecular biology (Clifton, N.J.) · 2023Review
- Single-cell multiomics analyses of spindle-transferred human embryos suggest a mostly normal embryonic development.PLoS biology · 2022Article
- Human germline nuclear transfer to overcome mitochondrial disease and failed fertilization after ICSI.Journal of assisted reproduction and genetics · 2022Article
- Natural and Artificial Mechanisms of Mitochondrial Genome Elimination.Life (Basel, Switzerland) · 2021Review
- Genetic Counseling and Assisted Reproductive Technologies.Cold Spring Harbor perspectives in medicine · 2020Review
- Three-parent babies: Mitochondrial replacement therapies.JBRA assisted reproduction · 2020Review
- Principles of and strategies for germline gene therapy.Nature medicine · 2019Review
- How bans on germline editing deprive patients with mitochondrial disease.Nature biotechnology · 2019Article
- Mitochondrial disease genetics update: recent insights into the molecular diagnosis and expanding phenotype of primary mitochondrial disease.Current opinion in pediatrics · 2018Review
- Mitochondrial Disease: Advances in clinical diagnosis, management, therapeutic development, and preventative strategies.Current genetic medicine reports · 2018Article
- Assisted reproductive technologies to prevent human mitochondrial disease transmission.Nature biotechnology · 2017Article
- A Mitocentric View of Alzheimer's Disease.Molecular neurobiology · 2017Review
- Mitochondrial genome inheritance and replacement in the human germline.The EMBO journal · 2017Article
- Genetic Counselling for Maternally Inherited Mitochondrial Disorders.Molecular diagnosis & therapy · 2017Review
Corrections and comments
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Authors and funding
4 authors.
Shoukhrat MitalipovDivision of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA; Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR 97239, USA. Electronic address: mitalipo@ohsu.edu.
Paula AmatoDivision of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR 97239, USA.
Samuel ParryDivision of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
Marni J FalkDivisions of Human Genetics and Metabolic Disease, Department of Pediatrics, The Children's Hospital of Philadelphia and University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
Funding
Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9MHistocompatible Primate Embryonic Stem CellsR01HD057121 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI MITALIPOV, SHOUKHRAT · 2009 to 2013
$3.4MMitochondrial Gene TherapyR01HD063276 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI MITALIPOV, SHOUKHRAT · 2010 to 2014
$3.0MAltered Nuclear TransferR01HD059946 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI MITALIPOV, SHOUKHRAT · 2010 to 2014
$2.7MEvaluation of stem cell-derived retinal pigment epithelial cells for retinal diseR01EY021214 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI NEURINGER, MARTHA · 2011 to 2015
$2.1MNEI NIH HHS R01 EY021214NEI NIH HHS R01-EY021214NICHD NIH HHS R01 HD057121NICHD NIH HHS R01-HD057121NICHD NIH HHS R01 HD059946NICHD NIH HHS R01-HD059946NICHD NIH HHS R01 HD063276NICHD NIH HHS R01-HD063276NIDDK NIH HHS R03-DK082446NIH HHS P51 OD011092NIH HHS P51-OD011092
Abstract
PubMed holds no abstract for this paper.
Indexed as
AnimalsBlastocystCell DivisionDNA, MitochondrialEmbryonic DevelopmentFemaleHaplotypesMacaca mulattaOocytesPregnancyDNA, Mitochondrial
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.