ArticleCurrent biology : CB2014
Maternal origins of developmental reproducibility.
Article in Current biology : CB, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Neighborhood-informed positional information for precise cell identity specification.Molecular systems biology · 2026Article
- Gap junctions allow transfer of metabolites between germ cells and somatic cells to promote germ cell growth in the Drosophila ovary.PLoS biology · 2025Article
- Transcription factor clusters as information transfer agents.Science advances · 2025Article
- Scale invariance in early embryonic development.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
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- Precise and scalable self-organization in mammalian pseudo-embryos.Nature structural & molecular biology · 2024Article
- Identification of high sugar diet-induced dysregulated metabolic pathways in muscle using tissue-specific metabolic models inbioRxiv : the preprint server for biology · 2024Article
- Scale invariance in early embryonic development.ArXiv · 2023Article
- Incorporation of CENP-A/CID into centromeres during early Drosophila embryogenesis does not require RNA polymerase II-mediated transcription.Chromosoma · 2022Article
- Synthetic reconstruction of theeLife · 2022Article
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- The many bits of positional information.Development (Cambridge, England) · 2021Review
- Evolution of larval segment position across 12 Drosophila species.Evolution; international journal of organic evolution · 2020Article
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- Ordered patterning of the sensory system is susceptible to stochastic features of gene expression.eLife · 2020Article
- Article
- Article
- Fishing forward and reverse: Advances in zebrafish phenomics.Mechanisms of development · 2018Review
- Single mRNA Molecule Detection in Drosophila.Methods in molecular biology (Clifton, N.J.) · 2018Article
- Cortical movement of Bicoid in early Drosophila embryos is actin- and microtubule-dependent and disagrees with the SDD diffusion model.PloS one · 2017Article
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Authors and funding
4 authors.
Funding
Abstract
Cell fate decisions during multicellular development are precisely coordinated, leading to highly reproducible macroscopic structural outcomes [1-3]. The origins of this reproducibility are found at the molecular level during the earliest stages of development when patterns of morphogen molecules emerge reproducibly [4, 5]. However, although the initial conditions for these early stages are determined by the female during oogenesis, it is unknown whether reproducibility is perpetuated from oogenesis or reacquired by the zygote. To address this issue in the early Drosophila embryo, we sought to count individual maternally deposited bicoid mRNA molecules and compare variability between embryos with previously observed fluctuations in the Bicoid protein gradient [6, 7]. Here, we develop independent methods to quantify total amounts of mRNA in individual embryos and show that mRNA counts are highly reproducible between embryos to within ~9%, matching the reproducibility of the protein gradient. Reproducibility emerges from perfectly linear feedforward processes: changing the genetic dosage in the female leads to proportional changes in both mRNA and protein numbers in the embryo. Our results indicate that the reproducibility of the morphological structures of embryos originates during oogenesis, which is when the expression of maternally provided patterning factors is precisely controlled.
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