Evidence map›Paper›PMID 24856065›Full record

ArticleBioorganic & medicinal chemistry letters2014

Separating the isomers--efficient synthesis of the N-hydroxysuccinimide esters of 5 and 6-carboxyfluorescein diacetate and 5 and 6-carboxyrhodamine B.

Aurélie Brunet, Tashfeen Aslam, Mark Bradley

Abstract read
In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Aurélie BrunetSchool of Chemistry, EaStChem, University of Edinburgh, West Mains Road, Edinburgh EH9 3JJ, UK.
Tashfeen AslamSchool of Chemistry, EaStChem, University of Edinburgh, West Mains Road, Edinburgh EH9 3JJ, UK.
Mark BradleySchool of Chemistry, EaStChem, University of Edinburgh, West Mains Road, Edinburgh EH9 3JJ, UK. Electronic address: mark.bradley@ed.ac.uk.

Funding

Medical Research Council
6 · The paper itself

Abstract

Diacetate protection of 5 and 6-carboxyfluorescein followed by synthesis of the N-hydroxysuccinimide esters allowed ready separation of the two isomers on a multi-gram scale. The 5 and 6-carboxyrhodamine B N-hydroxysuccinimide esters were also readily synthesised and separated.

Indexed as

EstersFluoresceinsMolecular StructureRhodaminesStereoisomerismSuccinimides5-carboxyfluorescein diacetate6-carboxyfluorescein diacetateEstersFluoresceinsN-hydroxysuccinimideRhodaminesSuccinimides5(6)-CarboxyfluoresceinCarboxyfluorescein diacetateN-Hydroxysuccinimide esterRhodamine B

Identifiers

PMID24856065
PMCPMC4090417

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.