Evidence map›Paper›PMID 24855985›Full record

ArticleJournal of the International AIDS Society2014

Maternal hepatitis B and infant infection among pregnant women living with HIV in South Africa.

Christopher J Hoffmann, Fildah Mashabela, Silvia Cohn, Jennifer D Hoffmann, Sanjay Lala, Neil A Martinson, Richard E Chaisson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the International AIDS Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Christopher J HoffmannCenter for TB Research, School of Medicine, Johns Hopkins University, Baltimore, MD, USA; choffmann@jhmi.edu.
Fildah MashabelaPerinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa.
Silvia CohnCenter for TB Research, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Jennifer D HoffmannCenter for TB Research, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Sanjay LalaDepartment of Pediatrics and Child Health, Chris Hani Baragwanath Academic Hospital, University of the Witwatersrand, Johannesburg, South Africa.
Neil A MartinsonCenter for TB Research, School of Medicine, Johns Hopkins University, Baltimore, MD, USA; Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa.
Richard E ChaissonCenter for TB Research, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Johns Hopkins University · USChris Hani Baragwanath Hospital · ZAUniversity of the Witwatersrand · ZA

Funding

Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Richard E. Chaisson · 2012 to 2026
$67.0M
Impact of TB on Outcome of HIV in Pregnant WomenR01HD064354 · NICHD · JOHNS HOPKINS UNIVERSITY · PI CHAISSON, RICHARD E. · 2010 to 2014
$3.0M
CAUSES OF AND ASSOCIATIONS WITH DEATH DURING LONG TERM HAART IN AFRICAK23AI083099 · NIAID · JOHNS HOPKINS UNIVERSITY · PI HOFFMANN, CHRISTOPHER J · 2010 to 2014
$671k
NIAID NIH HHS K23 AI083099NIAID NIH HHS K23-AI083099NIAID NIH HHS P30 AI094189NIAID NIH HHS P30-AI094189NICHD NIH HHS R01 HD064354NICHD NIH HHS R01-HD064354
6 · The paper itself

Abstract

introductionGlobally, hepatitis B virus (HBV) infection is the leading cause of liver-related mortality. Newborn vaccination, maternal antiviral therapy and administering hepatitis B immune globulin shortly after birth can greatly reduce the risk of perinatal and infant infection. However, evidence-based policy regarding these interventions in Africa is hampered by gaps in knowledge of HBV epidemiology. We describe maternal chronic hepatitis B (CHB) prevalence and infant infection during the first year of life within a cohort of women living with HIV.

methodsWe recruited and prospectively followed pregnant women living with HIV and their infants from prenatal clinics in an urban area of South Africa. Hepatitis B surface antigen, anti-hepatitis B surface antibodies and HBV DNA were assessed in all women. Hepatitis B testing was also performed at 6 and 52 weeks for all infants born to mothers with either positive surface antigen or detectable HBV DNA.

resultsWe enrolled 189 women with a median age of 29 years and median CD4 count of 348 cells/mm(3). Fourteen had a positive surface antigen (7.4%), of which six were positive for "e" antigen. An additional three had detectable HBV DNA without positive surface antigen. One infant developed CHB and three others had evidence of transmission based on positive HBV DNA assays. HBV vaccinations were delivered at six weeks of life to all infants.

conclusionsOur findings highlight the risk of peripartum HBV transmission in this setting. Approaches to reducing this transmission should be considered.

Indexed as

AdultFemaleHepatitis BHepatitis B Surface AntigensHIV InfectionsHumansInfantInfant, NewbornInfectious Disease Transmission, VerticalPregnancyPrevalenceSouth AfricaHepatitis B Surface AntigensAfricaHBVHIVoccult HBVperipartumtransmissionvaccination

Identifiers

PMID24855985
PMCPMC4032505
OpenAlexW1980464533

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.