ArticleThe Journal of experimental biology2014
Social status differences regulate the serotonergic system of a cichlid fish, Astatotilapia burtoni.
Article in The Journal of experimental biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 48 citations in OpenAlex.
- Organization of Serotonergic Cell Populations in the Brain and Spinal Cord of the Short-Lived African Turquoise Killifish.Biology · 2025Article
- Pheromone Perception in Fish: Mechanisms and Modulation by Internal Status.Integrative and comparative biology · 2023Review
- Neuroendocrine mechanisms contributing to the coevolution of sociality and communication.Frontiers in neuroendocrinology · 2023Review
- Identification and Characterization of 5-HT Receptor 1 fromInternational journal of molecular sciences · 2023Article
- Social stress-induced serotonin dysfunction activates spexin in male Nile tilapia (Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- Comparing behavioral performance and physiological responses of Sebastes schlegelii with different aggressiveness.Fish physiology and biochemistry · 2022Article
- Fish self-awareness: limits of current knowledge and theoretical expectations.Animal cognition · 2022Review
- Neural systems that facilitate the representation of social rank.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Brief Developmental Exposure to Fluoxetine Causes Life-Long Alteration of the Brain Transcriptome in Zebrafish.Frontiers in endocrinology · 2022Article
- Sex-dependent effects of social status on the regulation of arginine-vasopressin (AVP) V1a, oxytocin (OT), and serotonin (5-HT) 1A receptor binding and aggression in Syrian hamsters (Mesocricetus auratus).Hormones and behavior · 2021Article
- Sexual Dimorphism in Aggression: Sex-Specific Fighting Strategies Across Species.Frontiers in behavioral neuroscience · 2021Review
- Changes in Aggressive Behavior, Cortisol and Brain Monoamines during the Formation of Social Hierarchy in Black Rockfish (Animals : an open access journal from MDPI · 2020Article
- Time-Dependent Effects of Acute Handling on the Brain Monoamine System of the SalmonidFrontiers in neuroscience · 2020Article
- Dietary L-tryptophan modulates agonistic behavior and brain serotonin in male dyadic contests of a cichlid fish.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2019Article
- Male dominance status regulates odor-evoked processing in the forebrain of a cichlid fish.Scientific reports · 2019Article
- Neural and behavioural correlates of repeated social defeat.Scientific reports · 2018Article
- Social Defeat Stress Decreases mRNA for Monoamine Oxidase A and Increases 5-HT Turnover in the Brain of Male Nile Tilapia (Frontiers in pharmacology · 2018Article
- Expression of RING Finger Protein 38 in Serotonergic Neurons in the Brain of Nile Tilapia,Frontiers in neuroanatomy · 2018Article
- RING Finger Protein 38 Is a Neuronal Protein in the Brain of Nile Tilapia,Frontiers in neuroanatomy · 2017Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Serotonin (5-HT) inhibits aggression and modulates aspects of sexual behaviour in many species, but the mechanisms responsible are not well understood. Here, we exploited the social dominance hierarchy of Astatotilapia burtoni to understand the role of the serotonergic system in long-term maintenance of social status. We identified three populations of 5-HT cells in dorsal and ventral periventricular pretectal nuclei (PPd, PPv), the nucleus of the paraventricular organ (PVO) and raphe. Dominant males had more 5-HT cells than subordinates in the raphe, but the size of these cells did not differ between social groups. Subordinates had higher serotonergic turnover in the raphe and preoptic area (POA), a nucleus essential for hypothalamic-pituitary-gonadal (HPG) axis function. The relative abundance of mRNAs for 5-HT receptor (5-HTR) subtypes 1A and 2A (htr1a, htr2a) was higher in subordinates, a difference restricted to the telencephalon. Because social status is tightly linked to reproductive capacity, we asked whether serotonin turnover and the expression of its receptors correlated with testes size and circulating levels of 11-ketotestosterone (11-KT). We found negative correlations between both raphe and POA serotonin turnover and testes size, as well as between htr1a mRNA levels and circulating 11-KT. Thus, increased serotonin turnover in non-aggressive males is restricted to specific brain nuclei and is associated with increased expression of 5-HTR subtypes 1A and 2A exclusively in the telencephalon.
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