Evidence map›Paper›PMID 24855613›Full record

ArticleAnnals of rehabilitation medicine2014

Neuroradiological and neurophysiological characteristics of patients with dyskinetic cerebral palsy.

Byung-Hyun Park, Sung-Hee Park, Jeong-Hwan Seo, Myoung-Hwan Ko, Gyung-Ho Chung

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Article in Annals of rehabilitation medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

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7citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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7 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Byung-Hyun ParkDepartment of Physical Medicine and Rehabilitation, Chonbuk National University Medical School, Jeonju, Korea.
Sung-Hee ParkDepartment of Physical Medicine and Rehabilitation, Chonbuk National University Medical School, Jeonju, Korea.
Jeong-Hwan SeoDepartment of Physical Medicine and Rehabilitation, Chonbuk National University Medical School, Jeonju, Korea.
Myoung-Hwan KoDepartment of Physical Medicine and Rehabilitation, Chonbuk National University Medical School, Jeonju, Korea.
Gyung-Ho ChungDepartment of Radiology, Chonbuk National University Medical School, Jeonju, Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate neuroradiological and neurophysiological characteristics of patients with dyskinetic cerebral palsy (CP), by using magnetic resonance imaging (MRI), voxel-based morphometry (VBM), diffusion tensor tractography (DTT), and motor evoked potential (MEP).

methodsTwenty-three patients with dyskinetic CP (13 males, 10 females; mean age 34 years, range 16-50 years) were participated in this study. Functional evaluation was assessed by the Gross Motor Functional Classification System (GMFCS) and Barry-Albright Dystonia Scale (BADS). Brain imaging was performed on 3.0 Tesla MRI, and volume change of the grey matter was assessed using VBM. The corticospinal tract (CST) and superior longitudinal fasciculus (SLF) were analyzed by DTT. MEPs were recorded in the first dorsal interossei, the biceps brachii and the deltoid muscles.

resultsMean BADS was 16.4±5.0 in ambulatory group (GMFCS levels I, II, and III; n=11) and 21.3±3.9 in non-ambulatory group (GMFCS levels IV and V; n=12). Twelve patients showed normal MRI findings, and eleven patients showed abnormal MRI findings (grade I, n=5; grade II, n=2; grade III, n=4). About half of patients with dyskinetic CP showed putamen and thalamus lesions on MRI. Mean BADS was 20.3±5.7 in normal MRI group and 17.5±4.0 in abnormal MRI group. VBM showed reduced volume of the hippocampus and parahippocampal gyrus. In DTT, no abnormality was observed in CST, but not in SLF. In MEPs, most patients showed normal central motor conduction time.

conclusionThese results support that extrapyramidal tract, related with basal ganglia circuitry, may be responsible for the pathophysiology of dyskinetic CP rather than CST abnormality.

Indexed as

Cerebral palsyDiffusion tensor imagingMagnetic resonance imagingMotor evoked potentials

Identifiers

PMID24855613
PMCPMC4026605

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