Evidence map›Paper›PMID 24855564›Full record

ArticlePharmacology research & perspectives2014

Fibrinogen α-chain-derived peptide is upregulated in hippocampus of rats exposed to acute morphine injection and spontaneous alternation testing.

Agatha E Maki, Kenneth A Morris, Kasia Catherman, Xian Chen, Nathan G Hatcher, Paul E Gold, Jonathan V Sweedler

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacology research & perspectives, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Agatha E MakiBeckman Institute (A.E.M., K.C., X.C., N.G.H., J.V.S.), Neuroscience Program (A.E.M., K.A.M., J.V.S.), and Department of Chemistry (K.C., X.C., N.G.H., J.V.S.), University of Illinois at Urbana-Champaign, Urbana, Illinois; Department of Biology, Syracuse University, Syracuse, New York (P.E.G.).
Kenneth A MorrisBeckman Institute (A.E.M., K.C., X.C., N.G.H., J.V.S.), Neuroscience Program (A.E.M., K.A.M., J.V.S.), and Department of Chemistry (K.C., X.C., N.G.H., J.V.S.), University of Illinois at Urbana-Champaign, Urbana, Illinois; Department of Biology, Syracuse University, Syracuse, New York (P.E.G.).
Kasia CathermanBeckman Institute (A.E.M., K.C., X.C., N.G.H., J.V.S.), Neuroscience Program (A.E.M., K.A.M., J.V.S.), and Department of Chemistry (K.C., X.C., N.G.H., J.V.S.), University of Illinois at Urbana-Champaign, Urbana, Illinois; Department of Biology, Syracuse University, Syracuse, New York (P.E.G.).
Xian ChenBeckman Institute (A.E.M., K.C., X.C., N.G.H., J.V.S.), Neuroscience Program (A.E.M., K.A.M., J.V.S.), and Department of Chemistry (K.C., X.C., N.G.H., J.V.S.), University of Illinois at Urbana-Champaign, Urbana, Illinois; Department of Biology, Syracuse University, Syracuse, New York (P.E.G.).
Nathan G HatcherBeckman Institute (A.E.M., K.C., X.C., N.G.H., J.V.S.), Neuroscience Program (A.E.M., K.A.M., J.V.S.), and Department of Chemistry (K.C., X.C., N.G.H., J.V.S.), University of Illinois at Urbana-Champaign, Urbana, Illinois; Department of Biology, Syracuse University, Syracuse, New York (P.E.G.).
Paul E GoldBeckman Institute (A.E.M., K.C., X.C., N.G.H., J.V.S.), Neuroscience Program (A.E.M., K.A.M., J.V.S.), and Department of Chemistry (K.C., X.C., N.G.H., J.V.S.), University of Illinois at Urbana-Champaign, Urbana, Illinois; Department of Biology, Syracuse University, Syracuse, New York (P.E.G.).
Jonathan V SweedlerBeckman Institute (A.E.M., K.C., X.C., N.G.H., J.V.S.), Neuroscience Program (A.E.M., K.A.M., J.V.S.), and Department of Chemistry (K.C., X.C., N.G.H., J.V.S.), University of Illinois at Urbana-Champaign, Urbana, Illinois; Department of Biology, Syracuse University, Syracuse, New York (P.E.G.).
University of Illinois Urbana-Champaign · USSyracuse University · US

Funding

The UIUC Neuroproteomics Center on Cell-Cell SignalingP30DA018310 · NIDA · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI Elena V Romanova · 2004 to 2026
$24.9M
AGING AND MEMORYR01AG007648 · NIA · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI GOLD, PAUL E. · 1990 to 2008
$1.5M
Protein synthesis inhibitor effects on neurotransmitters and memoryR21DA024129 · NIDA · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI GOLD, PAUL E. · 2007 to 2008
$304k
NIA NIH HHS R01 AG007648NIDA NIH HHS P30 DA018310NIDA NIH HHS R21 DA024129
6 · The paper itself

Abstract

Fibrinogen is a secreted glycoprotein that is synthesized in the liver, although recent in situ hybridization data support its expression in the brain. It is involved in blood clotting and is released in the brain upon injury. Here, we report changes in the extracellular levels of fibrinogen α-chain-derived peptides in the brain after injections of saline and morphine. More specifically, in order to assess hippocampus-related working memory, an approach pairing in vivo microdialysis with mass spectrometry was used to characterize extracellular peptide release from the hippocampus of rats in response to saline or morphine injection coupled with a spontaneous alternation task. Two fibrinopeptide A-related peptides derived from the fibrinogen α-chain-fibrinopeptide A (ADTGTTSEFIEAGGDIR) and a fibrinopeptide A-derived peptide (DTGTTSEFIEAGGDIR)-were shown to be consistently elevated in the hippocampal microdialysate. Fibrinopeptide A was significantly upregulated in rats exposed to morphine and spontaneous alternation testing compared with rats exposed to saline and spontaneous alternation testing (P < 0.001), morphine alone (P < 0.01), or saline alone (P < 0.01), respectively. The increase in fibrinopeptide A in rats subjected to morphine and a memory task suggests that a complex interaction between fibrinogen and morphine takes place in the hippocampus.

Indexed as

fibrinogenfibrinogen α-chain peptidesfibrinopeptide Ahippocampusin vivo microdialysismass spectrometrymorphine

Identifiers

PMID24855564
PMCPMC4024393
OpenAlexW2140825438

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.