Evidence map›Paper›PMID 24855554›Full record

ArticleInternational journal of stem cells2010

Reversal of Hepatic Fibrosis by Human CD34(+) Stem/Progenitor Cell Transplantation in Rats.

M T Abdel Aziz, Mf El Asmar, S Mostafa, H Salama, H M Atta, S Mahfouz, N K Roshdy, L A Rashed, D Sabry, N Hasan and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of stem cells, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 10 citations in OpenAlex.

  1. Comparison of the therapeutic effectiveness of human CD34International journal of physiology, pathophysiology and pharmacology · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

M T Abdel AzizDepartments of Medical Biochemistry, Faculty of Medicine, Ain Shams University.
Mf El AsmarMedical Biochemistry, Faculty of Medicine, Ain Shams University.
S MostafaDepartments of Medical Biochemistry, Faculty of Medicine, Ain Shams University.
H SalamaTropical Medicine, Cairo University, Cairo, Egypt.
H M AttaDepartments of Medical Biochemistry, Faculty of Medicine, Ain Shams University.
S MahfouzPathology, Cairo University, Cairo, Egypt.
N K RoshdyDepartments of Medical Biochemistry, Faculty of Medicine, Ain Shams University.
L A RashedDepartments of Medical Biochemistry, Faculty of Medicine, Ain Shams University.
D SabryDepartments of Medical Biochemistry, Faculty of Medicine, Ain Shams University.
N HasanDepartments of Medical Biochemistry, Faculty of Medicine, Ain Shams University.
M MahmoudTropical Medicine, Cairo University, Cairo, Egypt.
D ElderwyCommunity Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt.
Cairo University · EGAin Shams University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human umbilical cord blood (UCB) cells have many advantages as grafts for cell transplantation. Here, we transplant UCB cells into injured liver fibrosis, investigated the hepatic potential of UCB cells both in vitro and in vivo. a CCl4 rat model with liver fibrosis was prepared. Human (UCB) CD34(+) stem cell was separated with MACS (magnetic cell sorting). Cells were cultured with and without hepatic differentiation medium. Rats were divided into 3 groups; group (1): control healthy, group (2): CCl4 injected rats and group 3: CCl4/CD34(+)injected rats with human differentiated and undifferentiated cells through intrahepatic (IH) and intravenous (IV) routes. A significant elevation was detected in serum albumin in CCl4/CD34(+) compared to the CCl4 group (p<0.001). Serum ALT, had a significant decrease of its level after administration of stem cells compared to the CCl4 group (p<0.001). However, it was still significantly higher than control (p<0.001) with no significant difference between the groups that received stem cells. Histopathological examination of liver tissue showed that stem cells have a significant antifibrotic effect. Concerning gene expression, the collagen gene (rat) was highly expressed in the CCl4 group whereas its expression was significantly decreased after administration of stem cells. Human albumin and matrix metalloproteinase (MMP2) genes were expressed in liver tissues in the groups that received stem cells. Highest expression was in the group that received un-differentiated cells I.V. human UCB CD34(+) stem cells can ameliorate liver fibrosis in rats.

Indexed as

CCl4 liver fibrosisHumanized ratStem cell therapyUmbilical cord blood CD34+

Identifiers

PMID24855554
PMCPMC4021810
OpenAlexW2037825930

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.