Evidence map›Paper›PMID 24855283›Full record

ReviewClinical journal of the American Society of Nephrology : CJASN2014

Distal convoluted tubule.

Arohan R Subramanya, David H Ellison

Open access · hybridAbstract readReview
In one paragraph

Review in Clinical journal of the American Society of Nephrology : CJASN, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 138 papers.

0numbers the graph read from it
0cells of the map it votes in
138citing papers in PubMed
9.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

138 citing papers in PubMed, 285 citations in OpenAlex.

  1. Trial
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  8. From Single-Cell Clusters to Causality: ITCH Engagement for CKD Uncovered by Integrative Analysis of MR and MAGMA.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
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  10. Review
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  18. A lipid atlas of the human kidney.Science advances · 2025
    Article
  19. Review
  20. Article

78 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Arohan R SubramanyaDepartments of Medicine and Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania; ars129@pitt.edu.
David H EllisonDepartments of Medicine and Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon; and Portland Veterans Affairs Medical Center, Portland, Oregon.
Portland VA Medical Center · USUniversity of Pittsburgh · US

Funding

Single Nephron and MetabolomicsP30DK079307 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R · 2008 to 2022
$13.4M
WNK Kinase Regulation of Thiazide-sensitive NaCl TransportR01DK051496 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI David Hoadley Ellison, CHAO-LING YANG · 1998 to 2026
$8.4M
Control of the Renal WNK Signaling Pathway by Phase TransitionsR01DK098145 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AYLIN RACHEL RODAN, AROHAN R SUBRAMANYA · 2014 to 2026
$4.2M
Molecular pathogenesis of calcineurin inhibitor-induced hypertensionR01DK095841 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI ELLISON, DAVID H, YANG, CHAO-LING · 2012 to 2015
$1.5M
NIDDK NIH HHS P30 DK079307NIDDK NIH HHS P30-DK079307NIDDK NIH HHS R01 DK051496NIDDK NIH HHS R01 DK095841NIDDK NIH HHS R01-DK095841NIDDK NIH HHS R01 DK098145NIDDK NIH HHS R01-DK098145NIDDK NIH HHS R01-DK51496
6 · The paper itself

Abstract

The distal convoluted tubule is the nephron segment that lies immediately downstream of the macula densa. Although short in length, the distal convoluted tubule plays a critical role in sodium, potassium, and divalent cation homeostasis. Recent genetic and physiologic studies have greatly expanded our understanding of how the distal convoluted tubule regulates these processes at the molecular level. This article provides an update on the distal convoluted tubule, highlighting concepts and pathophysiology relevant to clinical practice.

Indexed as

CalciumCations, DivalentEpithelial Sodium ChannelsHumansKidney Tubules, DistalMagnesiumPotassiumPotassium Channels, Inwardly RectifyingProtein Serine-Threonine KinasesRenal ReabsorptionSignal TransductionSodiumSodium ChlorideSolute Carrier Family 12, Member 3CalciumCations, DivalentEpithelial Sodium ChannelsMagnesiumOXSR1 protein, humanPotassiumPotassium Channels, Inwardly RectifyingProtein Serine-Threonine KinasesSodiumSodium ChlorideSolute Carrier Family 12, Member 3STK39 protein, humandistal tubulemineral metabolismNa transportpotassium channelsrenal physiology

Identifiers

PMID24855283
PMCPMC4255408
OpenAlexW2127951313

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.