ArticleScience (New York, N.Y.)2014
FoxP influences the speed and accuracy of a perceptual decision in Drosophila.
Article in Science (New York, N.Y.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 105 citations in OpenAlex.
- Control of water excretion in Hydra vulgaris by neural integration.Current biology : CB · 2026Article
- Conserved sleep disturbances in FOXP1 syndrome originate from developmental dysregulation of peptidergic signaling.The Journal of clinical investigation · 2026Article
- Developmental and genetic modulation of evidence integration dynamics in zebrafish sensorimotor decision-making.bioRxiv : the preprint server for biology · 2026Article
- Behavior choices amongst grooming, feeding and courting in Drosophila show contextual flexibility, not an absolute hierarchy of needs.The Journal of experimental biology · 2025Article
- Attentional switching in larval zebrafish.Science advances · 2025Article
- Ectopic sodium channel expression decreases excitability of Drosophila Kenyon cells.The Journal of physiology · 2025Article
- Evolutionary History of Bilaterian FoxP Genes: Complex Ancestral Functions and Evolutionary Changes Spanning 2R-WGD in the Vertebrate Lineage.Molecular biology and evolution · 2025Article
- The exponential distance rule-based network model predicts topology and reveals functionally relevant properties of theNetwork neuroscience (Cambridge, Mass.) · 2025Article
- Spatiotemporal dynamics of locomotor decisions inbioRxiv : the preprint server for biology · 2024Article
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- Flexible specificity of memory ineLife · 2023Article
- Transient photocurrents in a subthreshold evidence accumulator accelerate perceptual decisions.Nature communications · 2023Article
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- Structured sampling of olfactory input by the fly mushroom body.Current biology : CB · 2022Article
- Article
- FlyWire: online community for whole-brain connectomics.Nature methods · 2022Article
- Response competition between neurons and antineurons in the mushroom body.Current biology : CB · 2021Article
- A small, computationally flexible network produces the phenotypic diversity of song recognition in crickets.eLife · 2021Article
- Dopamine modulation of sensory processing and adaptive behavior in flies.Cell and tissue research · 2021Review
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3 authors at 1 institution in 1 country.
Funding
Abstract
Decisions take time if information gradually accumulates to a response threshold, but the neural mechanisms of integration and thresholding are unknown. We characterized a decision process in Drosophila that bears the behavioral signature of evidence accumulation. As stimulus contrast in trained odor discriminations decreased, reaction times increased and perceptual accuracy declined, in quantitative agreement with a drift-diffusion model. FoxP mutants took longer than wild-type flies to form decisions of similar or reduced accuracy, especially in difficult, low-contrast tasks. RNA interference with FoxP expression in αβ core Kenyon cells, or the overexpression of a potassium conductance in these neurons, recapitulated the FoxP mutant phenotype. A mushroom body subdomain whose development or function require the transcription factor FoxP thus supports the progression of a decision toward commitment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.