Evidence map›Paper›PMID 24855038›Full record

ArticleBehavioural brain research2014

Effect of diet on brain metabolites and behavior in spontaneously hypertensive rats.

Ana A Liso Navarro, Elif M Sikoglu, Cailin R Heinze, Ryan C Rogan, Vivienne A Russell, Jean A King, Constance M Moore

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In one paragraph

Article in Behavioural brain research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ana A Liso NavarroCenter for Comparative Neuroimaging, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA 01604, USA; Office Médico-Pédagogique, Department of Psychiatry, University of Geneva School of Medicine, 1 David Dufour, CP 50, 1211 Geneva 8, Switzerland.
Elif M SikogluCenter for Comparative Neuroimaging, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA 01604, USA.
Cailin R HeinzeDepartment of Clinical Sciences, Tufts Cummings School of Veterinary Medicine, North Grafton, MA 01536, USA.
Ryan C RoganCenter for Comparative Neuroimaging, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA 01604, USA.
Vivienne A RussellDivision of Physiology, School of Laboratory and Medical Sciences, University of KwaZulu-Natal, Durban 4041, South Africa.
Jean A KingCenter for Comparative Neuroimaging, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA 01604, USA.
Constance M MooreCenter for Comparative Neuroimaging, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA 01604, USA. Electronic address: Constance.Moore@umassmed.edu.

Funding

Possible Significance of Cholinergic Influence in ADHDR01DA025690 · NIDA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KING, JEAN A · 2010 to 2014
$1.8M
Glutamine and Glutamate in Children and Adolescents with Bipolar DisorderR01MH073998 · NIMH · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI MOORE, CONSTANCE M · 2008 to 2012
$1.5M
NIDA NIH HHS DA025690NIDA NIH HHS R01 DA025690NIMH NIH HHS MH073998NIMH NIH HHS R01 MH073998
6 · The paper itself

Abstract

Attention-deficit hyperactivity disorder (ADHD) is a heterogeneous psychiatric disorder affecting 5-10% of children. One of the suggested mechanisms underlying the pathophysiology of ADHD is insufficient energy supply to neurons. Here, we investigated the role of omega 3 fatty acids in altering neural energy metabolism and behavior of spontaneously hypertensive rats (SHR), which is an animal model of ADHD. To this end, we employed Proton Magnetic Resonance Spectroscopy ((1)H MRS) to evaluate changes in brain neurochemistry in the SHR following consumption of one of three experimental diets (starting PND 21): fish oil enriched (FOE), regular (RD) and animal fat enriched (AFE) diet. Behavioral tests were performed to evaluate differences in locomotor activity and risk-taking behavior (starting PND 44). Comparison of frontal lobe metabolites showed that increased amounts of omega 3 fatty acids decreased total Creatine levels (tCr), but did not change Glutamate (Glu), total N-Acetylaspartate (tNAA), Lactate (Lac), Choline (Cho) or Inositol (Ino) levels. Although behavior was not significantly affected by different diets, significant correlations were observed between brain metabolites and behavior in the open field and elevated plus maze. SHR with higher levels of brain tCr and Glu exhibited greater hyperactivity in a familiar environment. On the other hand, risk-taking exploration of the elevated plus maze's open arms correlated negatively with forebrain tNAA and Lac levels. These findings support the possible alteration in energy metabolites in ADHD, correlating with hyperactivity in the animal model. The data also suggest that omega 3 fatty acids alter brain energy and phospholipid metabolism.

Indexed as

Proton Magnetic Resonance SpectroscopyAnimalsAspartic AcidAttention Deficit Disorder with HyperactivityBrainCreatineDietary FatsDisease Models, AnimalEnergy MetabolismFish OilsFrontal LobeGlutamic AcidLocomotionMaleMaze LearningMotor ActivityAspartic AcidCreatineDietary FatsFish OilsGlutamic AcidN-acetylaspartateADHDEnergy metabolismFatty-acidNeuroimagingRat

Identifiers

PMID24855038
PMCPMC4100221

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.