ArticleInvestigative ophthalmology & visual science2014
Angiographic features of transgenic mice with increased expression of human serine protease HTRA1 in retinal pigment epithelium.
Article in Investigative ophthalmology & visual science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Article
- HTRA1-dependent proteolysis induces age-related retinal degeneration and exacerbates choroidal neovascularization.Disease models & mechanisms · 2025Article
- Article
- Altered Elastin Turnover, Immune Response, and Age-Related Retinal Thinning in a Transgenic Mouse Model With RPE-Specific HTRA1 Overexpression.Investigative ophthalmology & visual science · 2024Article
- Modeling complex age-related eye disease.Progress in retinal and eye research · 2024Review
- Combination of AIBP, apoA-I, and Aflibercept Overcomes Anti-VEGF Resistance in Neovascular AMD by Inhibiting Arteriolar Choroidal Neovascularization.Investigative ophthalmology & visual science · 2022Article
- Article
- Elastin turnover in ocular diseases: A special focus on age-related macular degeneration.Experimental eye research · 2022Review
- Evolving treatment paradigms for PCV.Eye (London, England) · 2022Review
- Classification of Transgenic Mice by Retinal Imaging Using SVMS.Computational intelligence and neuroscience · 2022Article
- Late-onset retinal degeneration pathology due to mutations in CTRP5 is mediated through HTRA1.Aging cell · 2019Article
- Pathologic study of early manifestations of polypoidal choroidal vasculopathy and pathogenesis of choroidal neo-vascularization.American journal of ophthalmology case reports · 2018Article
- Soft Drusen in Age-Related Macular Degeneration: Biology and Targeting Via the Oil Spill Strategies.Investigative ophthalmology & visual science · 2018Review
- HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model.EBioMedicine · 2018Article
- ER stress-induced aggresome trafficking of HtrA1 protects against proteotoxicity.Journal of molecular cell biology · 2017Article
- Proteolytic Degradation and Inflammation Play Critical Roles in Polypoidal Choroidal Vasculopathy.The American journal of pathology · 2017Article
- VISUALIZING RETINAL PIGMENT EPITHELIUM PHENOTYPES IN THE TRANSITION TO ATROPHY IN NEOVASCULAR AGE-RELATED MACULAR DEGENERATION.Retina (Philadelphia, Pa.) · 2016Article
- A functional approach to examine the role of HTRA1 versus ARMS2 in AMD.Investigative ophthalmology & visual science · 2014Article
- Animal models of age-related macular degeneration and their translatability into the clinic.Expert review of ophthalmology · 2014Article
- Role ofTaiwan journal of ophthalmologyReview
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
purposePolypoidal choroidal vasculopathy (PCV) is characterized by a branching vascular network (BVN) of choroid that terminates in polypoidal dilations. We have previously reported the generation of the first PCV model by transgenically expressing human HTRA1 (hHTRA1(+)), a multifunctional serine protease, in mouse RPE. The purpose of this study was to perform a comprehensive examination of the PCV phenotypes (e.g., lesion type and distribution) of hHTRA1(+) mice by a variety of in vivo imaging techniques.
methodsWe generated improved hHTRA1(+) mice with a more consistent phenotype. Transgenic mice were examined by indocyanine green angiography (ICGA), fluorescein angiography, funduscopy, and spectral-domain optical coherence tomography. In particular, we performed ICGA by tail vein injection of ICG to obtain high-quality ICGA comparable to human studies in terms of the three phases (early, middle, and late) of angiography.
resultsThe polyps can be detected in the early "fill-in" phase of ICGA, and most lesions become visible in the middle phase and are more distinct in the late phase with the fading of surrounding vessels. In addition to the two key features of PCV (polypoidal dilations and BVNs), hHTRA1(+) mice exhibit other features of PCV (i.e., late geographic hyperfluorescence, pigment epithelial detachment, and hyperfluorescent plaque). Polypoidal lesions appear as reddish orange nodules on funduscopy.
conclusionsTransgenic hHTRA1(+) mice exhibit a rich spectrum of "clinical" features that closely mimic human PCV. This animal model will serve as an invaluable tool for future mechanistic and translational studies of PCV and other forms of choroidal vasculopathies.
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