Evidence map›Paper›PMID 24854737›Full record

ArticlePloS one2014

Structural and functional brain alterations in end stage renal disease patients on routine hemodialysis: a voxel-based morphometry and resting state functional connectivity study.

Yingwei Qiu, Xiaofei Lv, Huanhuan Su, Guihua Jiang, Cheng Li, Junzhang Tian

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02650349 (StruCtuRal And FuncTional Brain Alterations by Conventional Spinal Cord Stimulation And High DensitY Stimulation), which is not on this map. Cited by 49 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02650349 nacompletednot on this mapstarted 2016, after this paper: background citation

StruCtuRal And FuncTional Brain Alterations by Conventional Spinal Cord Stimulation And High DensitY Stimulation: a Combined Voxel-based Morphometry and Resting State Functional Connectivity Study

TypeinterventionalSponsorUniversitair Ziekenhuis BrusselRan2016 to 2018Enrolled11ConditionsFailed Back Surgery SyndromeArmsfMRI
3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yingwei QiuDepartment of Medical Imaging, Guangdong No. 2 Provincial People's Hospital, Guangzhou, PR China; Department of Medical Imaging, The First Affiliated Hospital of Gannan Medical University, Ganzhou, PR China.
Xiaofei LvDepartments of Medical Imaging and Interventional Radiology, Cancer Center, Sun Yat-Sen University, Guangzhou, PR China.
Huanhuan SuDepartment of Medical Imaging, Guangdong No. 2 Provincial People's Hospital, Guangzhou, PR China.
Guihua JiangDepartment of Medical Imaging, Guangdong No. 2 Provincial People's Hospital, Guangzhou, PR China.
Cheng LiDepartment of Renal Transplantation, Guangdong No. 2 Provincial People's Hospital, Guangzhou, PR China.
Junzhang TianDepartment of Medical Imaging, Guangdong No. 2 Provincial People's Hospital, Guangzhou, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeCognitive impairment is a well-described phenomenon in end-stage renal disease (ESRD) patients. However, its pathogenesis remains poorly understood. The primary focus of this study was to examine structural and functional brain deficits in ESRD patients. MATERIALS AND

methodsThirty ESRD patients on hemodialysis (without clinical neurological disease) and 30 age- and gender-matched control individuals (without renal or neurological problems) were recruited in a prospective, single-center study. High-resolution structural magnetic resonance imaging (MRI) and resting state functional MRI were performed on both groups to detect the subtle cerebral deficits in ESRD patients. Voxel-based morphometry was used to characterize gray matter deficits in ESRD patients. The impact of abnormal morphometry on the cerebral functional integrity was investigated by evaluating the alterations in resting state functional connectivity when brain regions with gray matter volume reduction were used as seed areas.

resultsA significant decrease in gray matter volume was observed in ESRD patients in the bilateral medial orbito-prefrontal cortices, bilateral dorsal lateral prefrontal cortices, and the left middle temporal cortex. When brain regions with gray matter volume reduction were used as seed areas, the integration was found to be significantly decreased in ESRD patients in the fronto-cerebellum circuits and within prefrontal circuits. In addition, significantly enhanced functional connectivity was found between the prefrontal cortex and the left temporal cortex and within the prefrontal circuits.

conclusionsOur study revealed that both the structural and functional cerebral cortices were impaired in ESRD patients on routine hemodialysis.

Indexed as

Renal DialysisBrainCase-Control StudiesHumansKidney Failure, ChronicMagnetic Resonance ImagingProspective Studies

Identifiers

PMID24854737
PMCPMC4031192

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.