Trial reportJournal of neurology2014
Multiple sclerosis fatigue relief by bilateral somatosensory cortex neuromodulation.
Trial report in Journal of neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 3 syntheses or guidelines pooled it, 111 citations in OpenAlex.
- Brain stimulation for patients with multiple sclerosis: an umbrella review of therapeutic efficacy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Pooled it
- tDCS randomized controlled trials in no-structural diseases: a quantitative review.Scientific reports · 2021Pooled it
- Effects of Transcranial Direct Current Stimulation on Cognition, Mood, Pain, and Fatigue in Multiple Sclerosis: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2021Pooled it
- Transcranial direct current stimulation (tDCS) in the treatment of neuropsychiatric symptoms of long COVID.Scientific reports · 2024Trial
- Effect of transcranial direct current stimulation on post-stroke fatigue.Journal of neurology · 2021Trial
- Increased leg muscle fatigability during 2 mA and 4 mA transcranial direct current stimulation over the left motor cortex.Experimental brain research · 2020Trial
- Cortical neurodynamics changes mediate the efficacy of a personalized neuromodulation against multiple sclerosis fatigue.Scientific reports · 2019Trial
- A double-blind randomized control trial of transcranial direct current stimulation in post-stroke fatigue.Frontiers in neurologyTrial
- Fatigue relief is possible.Frontiers in integrative neuroscience · 2026Review
- Fatigue relief: the contribution of non-invasive neuromodulation (FAREviaNM).Frontiers in neuroscience · 2026Article
- The Association Between the Occurrence of Sensory Integration Disorders, Depression, and Chronic Fatigue in Patients with Relapsing-Remitting Multiple Sclerosis.Journal of clinical medicine · 2025Article
- tDCS and Cognitive Training for Fatigued and Cognitively Impaired People with Multiple Sclerosis: An SCED Study.Brain sciences · 2025Article
- Fatigue in Multiple Sclerosis: A Resting-State EEG Microstate Study.Brain topography · 2024Article
- Leveraging Artificial Intelligence to Optimize Transcranial Direct Current Stimulation for Long COVID Management: A Forward-Looking Perspective.Brain sciences · 2024Article
- Mechanisms of Post-Stroke Fatigue: A Follow-Up From the Third Stroke Recovery and Rehabilitation Roundtable.Neurorehabilitation and neural repair · 2024Review
- Musician's dystonia: an opinion on novel treatment strategies.Frontiers in neuroscience · 2024Article
- Personalized strategies of neurostimulation: from static biomarkers to dynamic closed-loop assessment of neural function.Frontiers in neuroscience · 2024Review
- Aberrant voxel-based degree centrality and functional connectivity in Parkinson's disease patients with fatigue.CNS neuroscience & therapeutics · 2023Article
- Auditory Personalization of EMDR Treatment to Relieve Trauma Effects: A Feasibility Study [EMDR+].Brain sciences · 2023Article
- Effects of repetitive twice-weekly transcranial direct current stimulations on fatigue and fatigability in people with multiple sclerosis.Scientific reports · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple sclerosis-related fatigue is highly common and often refractory to medical therapy. Ten fatigued multiple sclerosis patients received two blocks of 5-day anodal bilateral primary somatosensory areas transcranial direct current stimulation in a randomized, double-blind sham-controlled, cross-over study. The real neuromodulation by a personalized electrode, shaped on the MR-derived primary somatosensory cortical strip, reduced fatigue in all patients, by 26 % in average (p = 0.002), which did not change after sham (p = 0.901). Anodal tDCS over bilateral somatosensory areas was able to relief fatigue in mildly disabled MS patients, when the fatigue-related symptoms severely hamper their quality of life. These small-scale study results support the concept that interventions modifying the sensorimotor network activity balances could be a suitable non-pharmacological treatment for multiple sclerosis fatigue.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.