Evidence map›Paper›PMID 24854259›Full record

ArticleJournal of occupational and environmental medicine2014

A dose-response study of arsenic exposure and markers of oxidative damage in Bangladesh.

Kristin N Harper, Xinhua Liu, Megan N Hall, Vesna Ilievski, Julie Oka, Larissa Calancie, Vesna Slavkovich, Diane Levy, Abu Siddique, Shafiul Alam and 4 more

Open access · greenAbstract read
In one paragraph

Article in Journal of occupational and environmental medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Update of the risk assessment of inorganic arsenic in food.EFSA journal. European Food Safety Authority · 2024
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Kristin N HarperFrom the Departments of Environmental Health Sciences (Dr Harper, Ms Ilievski, Ms Oka, Ms Calancie, Ms Slavkovich, Dr Graziano, and Dr Gamble), Biostatistics (Dr Liu and Ms Levy), and Epidemiology (Dr Hall), Mailman School of Public Health, Columbia University, New York, NY; Columbia University Arsenic Project in Bangladesh (Mr Siddique and Mr Alam), Dhaka, Bangladesh; Lamont-Doherty Earth Observatory (Dr Mey and Dr van Geen), Columbia University, Palisades, NY; and Kingsbridge Community College (Dr Mey), New York, NY.
Xinhua Liu
Megan N Hall
Vesna Ilievski
Julie Oka
Larissa Calancie
Vesna Slavkovich
Diane Levy
Abu Siddique
Shafiul Alam
Jacob L Mey
Alexander van Geen
Joseph H Graziano
Mary V Gamble
MSD (Norway) · NO

Funding

Training CoreP42ES010349 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI NAVAS-ACIEN, ANA · 2000 to 2020
$53.6M
True Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MATTHEW S PERZANOWSKI · 1998 to 2026
$44.7M
Training Program in Cancer-Related Population SciencesR25CA094061 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI NEUGUT, ALFRED I. · 2002 to 2016
$5.9M
Folic Acid and Creatine as Therapeutic Approaches for Lowering Blood ArenicR01CA133595 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GAMBLE, MARY · 2009 to 2013
$2.3M
Biomarkers for Arsenic Toxicity: Genetics, Epigenetics and FolateR01ES017875 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GAMBLE, MARY · 2010 to 2013
$1.9M
Interrelationships among nutrients involved in one-carbon metabolism in BangladesK99ES018890 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HALL, MEGAN NINA · 2010 to 2011
$138k
NCI NIH HHS 5-R25-CA 094061NCI NIH HHS R01 CA133595NCI NIH HHS R25 CA094061NIEHS NIH HHS 1 P42 ES10349NIEHS NIH HHS K99 ES018890NIEHS NIH HHS P30 ES009089NIEHS NIH HHS P42 ES010349NIEHS NIH HHS R01 ES017875
6 · The paper itself

Abstract

objectiveTo evaluate the dose-response relationship between arsenic (As) exposure and markers of oxidative damage in Bangladeshi adults.

methodsWe recruited 378 participants drinking water from wells assigned to five water As exposure categories; the distribution of subjects was as follows: (1) less than 10 μg/L (n=76); (2) 10 to 100 μg/L (n=104); (3) 101 to 200 μg/L (n=86); (4) 201 to 300 μg/L (n=67); and (5) more than 300 μg/L (n=45). Arsenic concentrations were measured in well water, as well as in urine and blood. Urinary 8-oxo-2'-deoxyguanosine and plasma protein carbonyls were measured to assess oxidative damage.

resultsNone of our measures of As exposure were significantly associated with protein carbonyl or 8-oxo-2'-deoxyguanosine levels.

conclusionsWe found no evidence to support a significant relationship between long-term exposure to As-contaminated drinking water and biomarkers of oxidative damage among Bangladeshi adults.

Indexed as

Oxidative StressWater Pollution, Chemical8-Hydroxy-2'-DeoxyguanosineAdultArsenicBangladeshDeoxyguanosineDose-Response Relationship, DrugEnvironmental ExposureFemaleHumansMaleMiddle AgedProtein Carbonylation8-Hydroxy-2'-DeoxyguanosineArsenicDeoxyguanosine

Identifiers

PMID24854259
PMCPMC4050339
OpenAlexW2317265342

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.