Evidence map›Paper›PMID 24854185›Full record

ArticleAnnals of epidemiology2014

Serum cotinine and whole blood folate concentrations in pregnancy.

Adila Prasodjo, Christine M Pfeiffer, Zia Fazili, Yingying Xu, Stacey Liddy, Kimberly Yolton, David A Savitz, Bruce P Lanphear, Joseph M Braun

Registry-linked trialOpen access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of epidemiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00129324 (Neurobehavioral Effects of Prevalent Neurotoxicants in Children), which is not on this map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00129324 nacompletednot on this map

Neurobehavioral Effects of Prevalent Neurotoxicants in Children: A Cohort Study of the Cincinnati Center for Children's Environmental Health

TypeinterventionalSponsorNational Institute of Environmental Health Sciences (NIEHS)Ran2003 to 2018Enrolled468ConditionsEnvironmental Exposures, Child Development, Lead and Injury ReductionArmsLead Hazard Control Intervention, Injury Hazard Control Intervention
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Adila PrasodjoDepartment of Epidemiology, Brown University School of Public Health, Providence, RI.
Christine M PfeifferDivision of Laboratory Sciences, National Center for Environmental Health, Nutritional Biomarkers Branch, Centers for Disease Control and Prevention, Atlanta, GA.
Zia FaziliDivision of Laboratory Sciences, National Center for Environmental Health, Nutritional Biomarkers Branch, Centers for Disease Control and Prevention, Atlanta, GA.
Yingying XuDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Stacey LiddyDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Kimberly YoltonDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
David A SavitzDepartment of Epidemiology, Brown University School of Public Health, Providence, RI.
Bruce P LanphearFaculty of Health and Sciences, Simon Fraser University, Burnaby, Canada; Child and Family Research Institute, BC Children's and Women's Hospital, Vancouver, Canada.
Joseph M BraunDepartment of Epidemiology, Brown University School of Public Health, Providence, RI. Electronic address: joseph_braun_1@brown.edu.
Brown University · USCincinnati Children's Hospital Medical Center · USCenters for Disease Control and Prevention · USChild and Family Research Institute · CANational Center for Environmental Health · US

Funding

Spatial Analysis CoreR24HD041020 · NICHD · BROWN UNIVERSITY · PI LOGAN, JOHN R · 2001 to 2016
$7.4M
Study of Prevalent Neurotoxicants in ChildrenP01ES011261 · NIEHS · CINCINNATI CHILDRENS HOSP MED CTR · PI LANPHEAR, BRUCE P · 2001 to 2006
$6.4M
Longitudinal study of exposure to PBDEs and PFCs and child neurobehaviorR01ES020349 · NIEHS · UNIVERSITY OF CINCINNATI · PI CHEN, AIMIN, LANPHEAR, BRUCE P · 2011 to 2015
$2.9M
Prenatal Sex Steroids, Bisphenol A, Phthalates, and Sexually Dimorphic BehaviorsR00ES020346 · NIEHS · BROWN UNIVERSITY · PI BRAUN, JOSEPH M · 2013 to 2015
$683k
NICHD NIH HHS R24 HD041020NIEHS NIH HHS P01 ES011261NIEHS NIH HHS P01 ES11261NIEHS NIH HHS R00 ES020346NIEHS NIH HHS R01 ES020349
6 · The paper itself

Abstract

purposePrenatal tobacco smoke exposure may be associated with low maternal folate levels that increase the risk of adverse infant and child health outcomes by reducing folate availability during fetal development.

methodsUsing data from the Health Outcomes and Measures of the Environment Study, we examined the relationship between secondhand or active tobacco smoke exposure and whole blood folate concentrations in pregnant women from Cincinnati, Ohio (n = 362) at approximately 16-week gestation. We used multivariable linear regression to examine the association between continuous or categorical serum cotinine levels and whole blood folate levels, adjusting for sociodemographic, dietary, and perinatal variables.

resultsAfter adjustment for potential confounders, an interquartile range increases in serum cotinine concentration (0.012-0.224 ng/mL) was suggestively associated with decreased whole blood folate levels (β, -23 nmol/L; 95% confidence interval (CI), -49, 3; P value = .08). Compared with unexposed women, reductions in mean whole blood folate were observed among active smokers (β, -94, 95% CI, 195, 6 nmol/L; P value = .40); smaller reductions were observed among women with secondhand exposure (β, 26; CI, 84, 32 nmol/L; P value = .07).

conclusionsConsistent with prior studies, active smoking was associated with reduced whole blood folate levels among these pregnant women. Secondhand tobacco smoke exposures were associated with small and imprecise reductions in whole blood folate levels.

Indexed as

AdolescentAdultBiomarkersCotinineCross-Sectional StudiesDietFemaleFolic AcidHumansKentuckyLife StyleOhioPregnancyPrenatal CareSmokingSocioeconomic FactorsBiomarkersCotinineFolic AcidTobacco Smoke PollutionVitamin B ComplexEpidemiologyFolic acidPregnancySmokingTobacco smoke pollution

Identifiers

PMID24854185
PMCPMC4071615
OpenAlexW2071303320

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.