ArticleNeuron2014
Cell types, network homeostasis, and pathological compensation from a biologically plausible ion channel expression model.
Article in Neuron, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 168 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
168 citing papers in PubMed, 317 citations in OpenAlex.
- Article
- Sensitivity of a model oscillator to shifts in the voltage-dependence of one or more ionic currents.Journal of neurophysiology · 2026Article
- Scaling of Neuronal Growth and Excitability Through Separable mTORC1 and mTORC2 Pathways.bioRxiv : the preprint server for biology · 2026Article
- Compensatory coupling between leak and HCN conductances defines a low dimensional solution manifold in GPe neuron subtypes.Scientific reports · 2026Article
- When can neuronal activity-dependent homeostatic plasticity maintain circuit-level properties?Journal of computational neuroscience · 2026Article
- Activity-dependent neuromodulation and calcium homeostasis cooperate to produce robust and modulable neuronal function.PLoS computational biology · 2026Article
- The combined effects of temperature and salinity on the stomatogastric nervous system of two species of decapod crustacea.Journal of neurophysiology · 2026Article
- Persistent adaptation through dual-timescale regulation of ion channel properties.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Homeostatic preservation of action potential waveform by Notch and Nerfin-1.Current biology : CB · 2026Article
- Conductance relationships across compartments associated with bursting output in a model of a motor neuron in the crustacean cardiac ganglion.Journal of neurophysiology · 2026Article
- Triply Responsive Control of Ion Transport with an Artificial Channel Creates a Switchable AND to OR Logic Gate.Angewandte Chemie (International ed. in English) · 2026Article
- Data driven multiscale modelling of paroxysmal brain transitions using DC-coupled electrophysiological data.PloS one · 2026Article
- Deep Learning-Based Prediction of Individual CellBiosensors · 2025Article
- Article
- Persistent Adaptation through Dual-Timescale Regulation of Ion Channel Properties.bioRxiv : the preprint server for biology · 2025Article
- Higher-order interactions in neuronal function: From genes to ionic currents in biophysical models.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Targeting sodium channels - challenges for acute pain and the leap to chronic pain.Nature reviews. Neurology · 2025Review
- Calcium Homeostatic Feedback Control Predicts Atrial Fibrillation Initiation, Remodeling, and Progression.JACC. Clinical electrophysiology · 2025Article
- Homeostatic regulation of a motor circuit through temperature sensing rather than activity sensing.Current biology : CB · 2025Article
- Multicellular adaptation to electrophysiological perturbations analyzed by deterministic and stochastic bioelectrical models.Scientific reports · 2024Article
108 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
- Erratum issued
Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
Abstract
How do neurons develop, control, and maintain their electrical signaling properties in spite of ongoing protein turnover and perturbations to activity? From generic assumptions about the molecular biology underlying channel expression, we derive a simple model and show how it encodes an "activity set point" in single neurons. The model generates diverse self-regulating cell types and relates correlations in conductance expression observed in vivo to underlying channel expression rates. Synaptic as well as intrinsic conductances can be regulated to make a self-assembling central pattern generator network; thus, network-level homeostasis can emerge from cell-autonomous regulation rules. Finally, we demonstrate that the outcome of homeostatic regulation depends on the complement of ion channels expressed in cells: in some cases, loss of specific ion channels can be compensated; in others, the homeostatic mechanism itself causes pathological loss of function.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.