ArticleNeuron2014
New and distinct hippocampal place codes are generated in a new environment during septal inactivation.
Article in Neuron, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.
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Who cites it
78 citing papers in PubMed.
- Reproducible and predictable reorganization of place fields driven by grid subfield rate changes.bioRxiv : the preprint server for biology · 2026Article
- Medial septal theta stimulation enhances spatial working memory performance in rats.Learning & memory (Cold Spring Harbor, N.Y.) · 2025Article
- Article
- Space is a latent sequence: A theory of the hippocampus.Science advances · 2024Article
- Review
- Article
- Spontaneous Dynamics of Hippocampal Place Fields in a Model of Combinatorial Competition among Stable Inputs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Direct cortical inputs to hippocampal area CA1 transmit complementary signals for goal-directed navigation.Neuron · 2023Article
- Septo-hippocampal dynamics and the encoding of space and time.Trends in neurosciences · 2023Review
- Effects of theta phase precessing optogenetic intervention on hippocampal neuronal reactivation and spatial maps.iScience · 2023Article
- Optogenetic frequency scrambling of hippocampal theta oscillations dissociates working memory retrieval from hippocampal spatiotemporal codes.Nature communications · 2023Article
- Experience-dependent changes in hippocampal spatial activity and hippocampal circuit function are disrupted in a rat model of Fragile X Syndrome.Molecular autism · 2022Article
- Review
- The grid code for ordered experience.Nature reviews. Neuroscience · 2021Review
- A computational grid-to-place-cell transformation model indicates a synaptic driver of place cell impairment in early-stage Alzheimer's Disease.PLoS computational biology · 2021Article
- Time to put the mammillothalamic pathway into context.Neuroscience and biobehavioral reviews · 2021Review
- Perineuronal nets stabilize the grid cell network.Nature communications · 2021Article
- Optogenetic "low-theta" pacing of the septohippocampal circuit is sufficient for spatial goal finding and is influenced by behavioral state and cognitive demand.Hippocampus · 2020Article
- Diversity and function of corticopetal and corticofugal GABAergic projection neurons.Nature reviews. Neuroscience · 2020Review
- Cross-Frequency Phase-Amplitude Coupling between Hippocampal Theta and Gamma Oscillations during Recall Destabilizes Memory and Renders It Susceptible to Reconsolidation Disruption.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
18 more citing papers are in PubMed but not listed here.
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4 authors.
Funding
Abstract
The hippocampus generates distinct neural codes to disambiguate similar experiences, a process thought to underlie episodic memory function. Entorhinal grid cells provide a prominent spatial signal to hippocampus, and changes in their firing pattern could thus generate a distinct spatial code in each context. We examined whether we would preclude the emergence of new spatial representations in a novel environment during muscimol inactivation of the medial septal area, a manipulation known to disrupt theta oscillations and grid cell firing. We found that new, highly distinct configurations of place fields emerged immediately and remained stable during the septal inactivation. The new place code persisted when theta oscillations had recovered. Theta rhythmicity and feedforward input from grid cell networks were thus not required to generate new spatial representations in the hippocampus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.