Evidence map›Paper›PMID 24853928›Full record

ArticleNature protocols2014

Motif-based analysis of large nucleotide data sets using MEME-ChIP.

Wenxiu Ma, William S Noble, Timothy L Bailey

Open access · greenAbstract read
In one paragraph

Article in Nature protocols, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 143 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
143citing papers in PubMed, 1 pooled it
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

143 citing papers in PubMed, 1 synthesis or guideline pooled it, 253 citations in OpenAlex.

  1. Pooled it
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83 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Wenxiu MaDepartment of Genome Sciences, University of Washington, Seattle, Washington, USA.
William S Noble1] Department of Genome Sciences, University of Washington, Seattle, Washington, USA. [2] Department of Computer Science and Engineering, University of Washington, Seattle, Washington, USA.
Timothy L BaileyInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
Seattle University · USUniversity of Queensland · AU

Funding

The MEME Suite of motif-based sequence analysis toolsR01GM103544 · NIGMS · UNIVERSITY OF WASHINGTON · PI BAILEY, TIMOTHY L · 2012 to 2020
$2.4M
The MEME suite of motif-based sequence analysis toolsR01RR021692 · NCRR · UNIVERSITY OF WASHINGTON · PI NOBLE, WILLIAM STAFFORD · 2005 to 2011
$2.1M
Modeling Mammalian GenomesR01GM098039 · NIGMS · UNIVERSITY OF WASHINGTON · PI BLAU, C. ANTHONY · 2011 to 2013
$1.8M
NCRR NIH HHS R01 RR021692NIGMS NIH HHS R01 GM098039NIGMS NIH HHS R01 GM103544
6 · The paper itself

Abstract

MEME-ChIP is a web-based tool for analyzing motifs in large DNA or RNA data sets. It can analyze peak regions identified by ChIP-seq, cross-linking sites identified by CLIP-seq and related assays, as well as sets of genomic regions selected using other criteria. MEME-ChIP performs de novo motif discovery, motif enrichment analysis, motif location analysis and motif clustering, providing a comprehensive picture of the DNA or RNA motifs that are enriched in the input sequences. MEME-ChIP performs two complementary types of de novo motif discovery: weight matrix-based discovery for high accuracy; and word-based discovery for high sensitivity. Motif enrichment analysis using DNA or RNA motifs from human, mouse, worm, fly and other model organisms provides even greater sensitivity. MEME-ChIP's interactive HTML output groups and aligns significant motifs to ease interpretation. This protocol takes less than 3 h, and it provides motif discovery approaches that are distinct and complementary to other online methods.

Indexed as

AlgorithmsSoftwareBinding SitesChromatin ImmunoprecipitationCluster AnalysisHigh-Throughput Nucleotide SequencingNucleotide Motifs

Identifiers

PMID24853928
PMCPMC4175909
OpenAlexW2060445972

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.