Trial reportNutrients2014
Iron stores of breastfed infants during the first year of life.
Trial report in Nutrients, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 4 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Effect of iron supplements on cognitive development in children: an umbrella review.Frontiers in nutrition · 2026Pooled it
- Effect of probiotic and prebiotics supplementation on hemoglobin levels and iron absorption among women of reproductive age and children: a systematic review and meta-analysis.BMC nutrition · 2025Pooled it
- Effect of iron supplementation in healthy exclusively breastfed infants: a systematic review and meta-analysis.Frontiers in pediatrics · 2025Pooled it
- Vitamin D supplementation for term breastfed infants to prevent vitamin D deficiency and improve bone health.The Cochrane database of systematic reviews · 2020Pooled it
- Iron in breastfed infants and behavior at 3 years: a randomized trial.Scientific reports · 2026Trial
- Maternal anemia type during pregnancy is associated with anemia risk among offspring during infancy.Pediatric research · 2019Trial
- Iron Supplementation and Neurodevelopmental Outcomes in Infancy and Early Childhood: A Review.Children (Basel, Switzerland) · 2026Review
- Longitudinal Plasma Ferritin in the First Year of Life in Relation to Maternal Status, Birth Characteristics, and Breastfeeding.Nutrients · 2026Observational
- Male sex and iron deficiency risk at 6 months: the mediating role of rapid weight gain.Frontiers in nutrition · 2026Article
- Maternal and infant serum ferritin concentrations across pregnancy and postpartum: a longitudinal study in Norway.Food & nutrition research · 2026Article
- Use of Different Iron Preparations for Prophylaxis and Effects on Iron Status in Infancy.Healthcare (Basel, Switzerland) · 2024Article
- Iron deficiency in healthy, term infants aged five months, in a pediatric outpatient clinic: a prospective study.BMC pediatrics · 2024Article
- Reticulocyte Hemoglobin Equivalent has Comparable Predictive Accuracy as Conventional Serum Iron Indices for Predicting Iron Deficiency and Anemia in a Nonhuman Primate model of Infantile Iron Deficiency.The Journal of nutrition · 2023Article
- Making every bite count: best practices for introducing foods during the complementary feeding period.The American journal of clinical nutrition · 2022Article
- Association of Gestational Hypertension with Anemia under 5 Years Old: Two Large Longitudinal Chinese Birth Cohorts.Nutrients · 2022Article
- Dietary Approaches to Iron Deficiency Prevention in Childhood-A Critical Public Health Issue.Nutrients · 2022Review
- Nutritional status and adequacy of feeding Practices in Infants and Toddlers 0-23.9 months living in the United Arab Emirates (UAE): findings from the feeding Infants and Toddlers Study (FITS) 2020.BMC public health · 2022Article
- Effects of iron deficiency and iron supplementation at the host-microbiota interface: Could a piglet model unravel complexities of the underlying mechanisms?Frontiers in nutrition · 2022Review
- Effect of using commercial pre-packaged baby foods on the Fe intake of 7-8 months old infants.Public health nutrition · 2021Article
- Effect of Daily Iron Supplementation on Infantile Iron Homeostasis in Preterm Infants.Frontiers in pediatrics · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The birth iron endowment provides iron for growth in the first months of life. We describe the iron endowment under conditions of low dietary iron supply. Subjects were infants participating in a trial of Vitamin D supplementation from 1 to 9 months. Infants were exclusively breastfed at enrollment but could receive complementary foods from 4 months but not formula. Plasma ferritin (PF) and transferrin receptor (TfR) were determined at 1, 2, 4, 5.5, 7.5, 9 and 12 months. At 1 month PF ranged from 38 to 752 µg/L and was only weakly related to maternal PF. PF declined subsequently and flattened out at 5.5 months. PF of females was significantly higher than PF of males except at 12 months. TfR increased with age and was inversely correlated with PF. PF and TfR tracked strongly until 9 months. Iron deficiency (PF < 10 µg/L) began to appear at 4 months and increased in frequency until 9 months. Infants with ID were born with low iron endowment. We concluded that the birth iron endowment is highly variable in size and a small endowment places infants at risk of iron deficiency before 6 months. Boys have smaller iron endowments and are at greater risk of iron deficiency than girls.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.