ArticleScandinavian journal of psychology2014
Longitudinal change in working memory as a function of APOE genotype in midlife and old age.
Article in Scandinavian journal of psychology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- The influence of socioeconomic factors and apolipoprotein ε genotype on cognitive outcomes in a multi-ethnic sample living with HCV and HIV.International journal of STD & AIDS · 2025Article
- Neurophysiological and other features of working memory in older adults at risk for dementia.Cognitive neurodynamics · 2024Article
- Dementia risk and thalamic nuclei volumetry in healthy midlife adults: the PREVENT Dementia study.Brain communications · 2024Article
- Interactive association of posttraumatic stress disorder, apolipoprotein ε4 genotype, and age on cognitive functioning.International journal of geriatric psychiatry · 2023Article
- The APOE ε4 allele in relation to pre- and postsurgical cognitive functioning of patients with primary brain tumors.European journal of neurology · 2021Article
- Superior short-term memory in APOE ε2 carriers across the age range.Behavioural brain research · 2021Article
- Positive Effect of Cognitive Reserve on Episodic Memory, Executive and Attentional Functions Taking Into Account Amyloid-Beta, Tau, and Apolipoprotein E Status.Frontiers in aging neuroscience · 2021Article
- Memory precision of object-location binding is unimpaired inBrain communications · 2021Article
- Short-term memory advantage for brief durations in human APOE ε4 carriers.Scientific reports · 2020Article
- Apolipoprotein E Homozygous ε4 Allele Status: A Deteriorating Effect on Visuospatial Working Memory and Global Brain Structure.Frontiers in neurology · 2019Article
- Dissociable effects of the apolipoprotein-E (APOE) gene on short- and long-term memories.Neurobiology of aging · 2019Article
- APOE influences working memory in non-demented elderly through an interaction with SPON1 rs2618516.Human brain mapping · 2018Article
- Apolipoprotein-E (Apoe) ε4 and cognitive decline over the adult life course.Translational psychiatry · 2018Article
- Genetic Risk for Age-Related Cognitive Impairment Does Not Predict Cognitive Performance in Middle Age.Journal of Alzheimer's disease : JAD · 2018Article
- Brain Aging and APOE ε4 Interact to Reveal Potential Neuronal Compensation in Healthy Older Adults.Frontiers in aging neuroscience · 2018Article
- Sex and APOE: A memory advantage in male APOE ε4 carriers in midlife.Cortex; a journal devoted to the study of the nervous system and behavior · 2017Article
- Interaction between C-reactive protein and cognitive functions according to APOE gene polymorphism in post-menopausal women.Archives of medical science : AMS · 2016Article
- Apolipoprotein ɛ4 breaks the association between declarative long-term memory and memory-based orienting of spatial attention in middle-aged individuals.Cortex; a journal devoted to the study of the nervous system and behavior · 2016Article
- Listening Comprehension in Middle-Aged Adults.American journal of audiology · 2015Article
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5 authors.
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Abstract
Previous investigations into whether the APOE-ε4 allele exerts cognitive effects at midlife have been inconclusive. We have advanced a "cognitive phenotype" hypothesis arguing that the ε4 allele of the apolipoprotein E gene (APOE) is associated with lower efficiency of neuronal plasticity thereby resulting in poorer cognitive performance independently of the pathology of Alzheimer's disease (Greenwood et al., ). This hypothesis is best tested at midlife, prior to the neuron loss associated with AD diagnosis. This hypothesis predicts that the ε4 allele would alter cognition regardless of age through plasticity mechanisms, but would not induce longitudinal decline in midlife. The alternative "prodrome" hypothesis predicts that the APOE-ε4 allele would be associated with longitudinal cognitive decline as early as midlife due to prodromal effects of AD. We tested these hypotheses with a working memory task in a large cross-sectional sample of cognitively screened APOE-ε4 carriers and non-carriers and also in a small longitudinal sample over 3 years. The sample was divided into middle-aged (mean age 50, range 40-59) and older (mean age 69, range 60-84) individuals. Cross-sectionally, we observed that older, but not middle-aged, APOE-ε4 carriers had lower accuracy than ε4 non-carriers, mainly under the hardest discrimination condition. Longitudinally, we observed increases in accuracy in middle-aged APOE-ε4 carriers, suggesting a cognitive phenotype that includes ability to benefit from experience. We observed a longitudinal decrease in older APOE-ε4 carriers, suggesting an AD prodrome.
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