ArticleBiophysical journal2014
Negative feedback synchronizes islets of Langerhans.
Article in Biophysical journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Frequency-Dependent Premature Differentiation of Pheochromocytoma Cells Exhibits Band-Pass Filter Behavior Correlation with Intracellular Enzyme Activation Kinetics.International journal of molecular sciences · 2025Article
- Unveiling islet heterogeneity using an automated microfluidic imaging system.Scientific reports · 2024Article
- A mechanism for slow rhythms in coordinated pancreatic islet activity.Biophysical journal · 2024Article
- Deconstructing the integrated oscillator model for pancreatic β-cells.Mathematical biosciences · 2023Article
- Coordination of pancreatic islet rhythmic activity by delayed negative feedback.American journal of physiology. Endocrinology and metabolism · 2022Article
- Building Biomimetic Potency Tests for Islet Transplantation.Diabetes · 2021Review
- Pancreas-on-a-Chip Technology for Transplantation Applications.Current diabetes reports · 2020Review
- Mathematical Modelling of Endocrine Systems.Trends in endocrinology and metabolism: TEM · 2019Review
- A Two-Pulse Cellular Stimulation Test Elucidates Variability and Mechanisms in Signaling Pathways.Biophysical journal · 2019Article
- Article
- Synchronization of pancreatic islets by periodic or non-periodic muscarinic agonist pulse trains.PloS one · 2019Article
- Release of Applied Mechanical Loading Stimulates Intercellular Calcium Waves in Drosophila Wing Discs.Biophysical journal · 2017Article
- New insights into mammalian signaling pathways using microfluidic pulsatile inputs and mathematical modeling.Integrative biology : quantitative biosciences from nano to macro · 2017Review
- Article
- Phase modulation of insulin pulses enhances glucose regulation and enables inter-islet synchronization.PloS one · 2017Article
- Critical and Supercritical Spatiotemporal Calcium Dynamics in Beta Cells.Frontiers in physiology · 2017Article
- Dual Detection System for Simultaneous Measurement of Intracellular Fluorescent Markers and Cellular Secretion.Analytical chemistry · 2016Article
- Glucose Oscillations Can Activate an Endogenous Oscillator in Pancreatic Islets.PLoS computational biology · 2016Article
- Measurement of the entrainment window of islets of Langerhans by microfluidic delivery of a chirped glucose waveform.Integrative biology : quantitative biosciences from nano to macro · 2015Article
- Integrated perfusion and separation systems for entrainment of insulin secretion from islets of Langerhans.Lab on a chip · 2015Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Insulin is released from the pancreas in pulses with a period of ~ 5 min. These oscillatory insulin levels are essential for proper liver utilization and perturbed pulsatility is observed in type 2 diabetes. What coordinates the many islets of Langerhans throughout the pancreas to produce unified oscillations of insulin secretion? One hypothesis is that coordination is achieved through an insulin-dependent negative feedback action of the liver onto the glucose level. This hypothesis was tested in an in vitro setting using a microfluidic system where the population response from a group of islets was input to a model of hepatic glucose uptake, which provided a negative feedback to the glucose level. This modified glucose level was then delivered back to the islet chamber where the population response was again monitored and used to update the glucose concentration delivered to the islets. We found that, with appropriate parameters for the model, oscillations in islet activity were synchronized. This approach demonstrates that rhythmic activity of a population of physically uncoupled islets can be coordinated by a downstream system that senses islet activity and supplies negative feedback. In the intact animal, the liver can play this role of the coordinator of islet activity.
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