ArticleBiophysical journal2014
Voltage and calcium dynamics both underlie cellular alternans in cardiac myocytes.
Article in Biophysical journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Beat-to-beat QT interval variability as a tool to detect the underlying cellular mechanisms of arrhythmias.The Journal of physiology · 2025Article
- The calcium transient coupled to the L-type calcium current attenuates cardiac alternans.Frontiers in physiology · 2024Article
- Fiber Organization Has Little Effect on Electrical Activation Patterns During Focal Arrhythmias in the Left Atrium.IEEE transactions on bio-medical engineering · 2023Article
- Article
- Image-Driven Modeling of Nanoscopic Cardiac Function: Where Have We Come From, and Where Are We Going?Frontiers in physiology · 2022Review
- Methodology for Cross-Talk Elimination in Simultaneous Voltage and Calcium Optical Mapping Measurements With Semasbestic Wavelengths.Frontiers in physiology · 2022Article
- Cardiac Alternans Occurs through the Synergy of Voltage- and Calcium-Dependent Mechanisms.Membranes · 2021Article
- Feedback control of calcium driven alternans in cardiac myocytes.Chaos (Woodbury, N.Y.) · 2020Article
- Prediction of the mechanical response of cardiac alternans by using an electromechanical model of human ventricular myocytes.Biomedical engineering online · 2019Article
- Mechanistic investigation of Ca2+ alternans in human heart failure and its modulation by fibroblasts.PloS one · 2019Article
- Increased Vulnerability to Atrial Fibrillation Is Associated With Increased Susceptibility to Alternans in Old Sheep.Journal of the American Heart Association · 2018Article
- Stochastic Pacing Inhibits Spatially Discordant Cardiac Alternans.Biophysical journal · 2017Article
- Hard real-time closed-loop electrophysiology with the Real-Time eXperiment Interface (RTXI).PLoS computational biology · 2017Article
- Dynamical effects of calcium-sensitive potassium currents on voltage and calcium alternans.The Journal of physiology · 2017Article
- From channels to systems: CaThe Journal of physiology · 2017Article
- Stochastic pacing reveals the propensity to cardiac action potential alternans and uncovers its underlying dynamics.The Journal of physiology · 2016Article
- Calcium-activated chloride current determines action potential morphology during calcium alternans in atrial myocytes.The Journal of physiology · 2016Article
- T-tubule disruption promotes calcium alternans in failing ventricular myocytes: mechanistic insights from computational modeling.Journal of molecular and cellular cardiology · 2015Article
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Authors and funding
4 authors.
Funding
Abstract
Cardiac alternans, a putative trigger event for cardiac reentry, is a beat-to-beat alternation in membrane potential and calcium transient. Alternans was originally attributed to instabilities in transmembrane ion channel dynamics (i.e., the voltage mechanism). As of this writing, the predominant view is that instabilities in subcellular calcium handling are the main underlying mechanism. That being said, because the voltage and calcium systems are bidirectionally coupled, theoretical studies have suggested that both mechanisms can contribute. To date, to our knowledge, no experimental evidence of such a dual role within the same cell has been reported. Here, a combined electrophysiological and calcium imaging approach was developed and used to illuminate the contributions of voltage and calcium dynamics to alternans. An experimentally feasible protocol, quantification of subcellular calcium alternans and restitution slope during cycle-length ramping alternans control, was designed and validated. This approach allows simultaneous illumination of the contributions of voltage and calcium-driven instability to total cellular instability as a function of cycle-length. Application of this protocol in in vitro guinea-pig left-ventricular myocytes demonstrated that both voltage- and calcium-driven instabilities underlie alternans, and that the relative contributions of the two systems change as a function of pacing rate.
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