Evidence map›Paper›PMID 24853749›Full record

ArticleBiophysical journal2014

Distinct features of the histone core structure in nucleosomes containing the histone H2A.B variant.

Masaaki Sugiyama, Yasuhiro Arimura, Kazuyoshi Shirayama, Risa Fujita, Yojiro Oba, Nobuhiro Sato, Rintaro Inoue, Takashi Oda, Mamoru Sato, Richard K Heenan and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Biophysical journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Solution conformational differences between conventional and CENP-A nucleosomes are accentuated by reversible deformation under high pressure.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Deuteration Aiming for Neutron Scattering.Biophysics and physicobiology · 2021
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Nucleosome structure and function.Chemical reviews · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Masaaki SugiyamaResearch Reactor Institute, Kyoto University, Kumatori, Osaka 590-0494, Japan. Electronic address: sugiyama@rri.kyoto-u.ac.jp.
Yasuhiro Arimura(‡)Laboratory of Structural Biology, Waseda University, Shinjuku-ku, Tokyo 162-8480, Japan.
Kazuyoshi Shirayama(‡)Laboratory of Structural Biology, Waseda University, Shinjuku-ku, Tokyo 162-8480, Japan.
Risa Fujita(‡)Laboratory of Structural Biology, Waseda University, Shinjuku-ku, Tokyo 162-8480, Japan.
Yojiro ObaResearch Reactor Institute, Kyoto University, Kumatori, Osaka 590-0494, Japan.
Nobuhiro SatoResearch Reactor Institute, Kyoto University, Kumatori, Osaka 590-0494, Japan.
Rintaro InoueResearch Reactor Institute, Kyoto University, Kumatori, Osaka 590-0494, Japan.
Takashi OdaGraduate School of Medical Life Science, Yokohama City University, Tsurumi, Yokohama 230-0045, Japan.
Mamoru SatoGraduate School of Medical Life Science, Yokohama City University, Tsurumi, Yokohama 230-0045, Japan.
Richard K HeenanISIS Facility, STFC Rutherford Appleton Laboratory, Didcot, OX11 0QX, UK.
Hitoshi Kurumizaka(‡)Laboratory of Structural Biology, Waseda University, Shinjuku-ku, Tokyo 162-8480, Japan. Electronic address: kurumizaka@waseda.jp.
Kyoto University Research Reactor Institute · JPYokohama City University · JPRutherford Appleton Laboratory · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nucleosomes containing a human histone variant, H2A.B, in an aqueous solution were analyzed by small-angle neutron scattering utilizing a contrast variation technique. Comparisons with the canonical H2A nucleosome structure revealed that the DNA termini of the H2A.B nucleosome are detached from the histone core surface, and flexibly expanded toward the solvent. In contrast, the histone tails are compacted in H2A.B nucleosomes compared to those in canonical H2A nucleosomes, suggesting that they bind to the surface of the histone core and/or DNA. Therefore, the histone tail dynamics may function to regulate the flexibility of the DNA termini in the nucleosomes.

Indexed as

HistonesHumansNucleosomesRotationHistonesNucleosomes

Identifiers

PMID24853749
PMCPMC4052288
OpenAlexW2038227807

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.