ReviewInflammation & allergy drug targets2014
Inflammaging in skin and other tissues - the roles of complement system and macrophage.
Review in Inflammation & allergy drug targets, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Aging and Herbal Interventions: Mechanistic Insights and Therapeutic Potential.Journal of cosmetic dermatology · 2025Pooled it
- Mitigation of ultraviolet-induced erythema and inflammation by para-hydroxycinnamic acid in human skin.International journal of cosmetic science · 2025Trial
- Dermal fibroblasts cultured from aged human skin display a pro-inflammatory phenotype.Journal of cell communication and signaling · 2026Article
- Antrodia cinnamomea extract exhibits anti-melanogenic and anti-photoaging effects: potential for cosmetic and dermatological applications.Scientific reports · 2026Article
- Colla Corii Asini regulate collagen regeneration in UV exposure-induced skin photoaging in mice.Chinese medicine · 2025Article
- Biotransformation by beta glucosidase enhances anti inflammatory metabolites in licorice using untargeted metabolomics.NPJ science of food · 2025Article
- Characterization of macrophages associated with human skin models exposed to UV radiation.Communications biology · 2024Article
- Pomegranate (Molecules (Basel, Switzerland) · 2024Review
- Emerging Perspectives of YAP/TAZ in Human Skin Epidermal and Dermal Aging.Annals of dermatology · 2024Review
- Research Progress in Skin Aging and Immunity.International journal of molecular sciences · 2024Review
- Review
- Natural Modulators of Key Signaling Pathways in Skin Inflammageing.Clinical, cosmetic and investigational dermatology · 2024Review
- Human ProbioticCells · 2023Article
- Signaling mechanisms underlying lymphatic vessel dysfunction in skin aging and possible anti-aging strategies.Biogerontology · 2023Review
- Skin microbiome attributes associate with biophysical skin ageing.Experimental dermatology · 2023Article
- New Insights into the Dermocosmetic Potential of the Red SeaweedAntioxidants (Basel, Switzerland) · 2023Article
- Effects of Bacterial Lysates and Metabolites on Collagen Homeostasis in TNF-α-Challenged Human Dermal Fibroblasts.Microorganisms · 2023Article
- Inflammaging and Immunosenescence as Part of Skin Aging-A Narrative Review.International journal of molecular sciences · 2023Review
- Skin Ageing: A Progressive, Multi-Factorial Condition Demanding an Integrated, Multilayer-Targeted Remedy.Clinical, cosmetic and investigational dermatology · 2023Review
- Evolutionary and genomic perspectives of brain aging and neurodegenerative diseases.Progress in brain research · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inflammaging refers to a continuous, low-grade inflammation associated with aging. Such chronic inflammatory response could build up with time and gradually causes tissue damage. It is considered as one of the driving forces for many age-related diseases such as diabetes, atherosclerosis, age-related macular degeneration (AMD), and skin aging. There is mounting evidence that indicates aging is driven by the pro-inflammatory cytokines and substances produced by our body's innate immune system. The macrophage and complement system, two important components of innate immune system, have attracted more and more attention since they appear to be involved in the pathogenesis of several inflammaging-associated diseases, such as AMD and atherosclerosis. This paper will review what we know about these two innate immune systems in the pathogenesis of AMD, atherosclerosis and skin aging.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.