ArticleInternational journal of pharmaceutics2014
pH-Responsive poly(itaconic acid-co-N-vinylpyrrolidone) hydrogels with reduced ionic strength loading solutions offer improved oral delivery potential for high isoelectric point-exhibiting therapeutic proteins.
Article in International journal of pharmaceutics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Recent Developments in Protein-Based Hydrogels for Advanced Drug Delivery Applications.Pharmaceutics · 2026Review
- Development and Optimization of Tamarind Gum-β-Cyclodextrin-g-Poly(Methacrylate) pH-Responsive Hydrogels for Sustained Delivery of Acyclovir.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Advanced biomedical hydrogels: molecular architecture and its impact on medical applications.Regenerative biomaterials · 2021Review
- Recent Advances in Smart Biomaterials for the Detection and Treatment of Autoimmune Diseases.Advanced functional materials · 2020Article
- QCM-D assay for quantifying the swelling, biodegradation, and protein adsorption of intelligent nanogels.Journal of applied polymer science · 2020Article
- Oral Drug Delivery Technologies-A Decade of Developments.The Journal of pharmacology and experimental therapeutics · 2019Review
- Multifunctional oral delivery systems for enhanced bioavailability of therapeutic peptides/proteins.Acta pharmaceutica Sinica. B · 2019Review
- pH-Responsive Microencapsulation Systems for the Oral Delivery of Polyanhydride Nanoparticles.Biomacromolecules · 2018Article
- Designing the new generation of intelligent biocompatible carriers for protein and peptide delivery.Acta pharmaceutica Sinica. B · 2018Review
- pH-Responsive carriers for oral drug delivery: challenges and opportunities of current platforms.Drug delivery · 2017Review
- Student award for outstanding research winner in the Ph.D. category for the 2017 society for biomaterials annual meeting and exposition, april 5-8, 2017, Minneapolis, Minnesota: Characterization of protein interactions with molecularly imprinted hydrogels that possess engineered affinity for high isoelectric point biomarkers.Journal of biomedical materials research. Part A · 2017Article
- pH-Sensitive stimulus-responsive nanocarriers for targeted delivery of therapeutic agents.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2016Review
- Design of pH-Responsive Biomaterials to Enable the Oral Route of Hematological Factor IX.Annals of biomedical engineering · 2016Article
- Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems.Chemical Society reviews · 2016Review
- pH-responsive and enzymatically-responsive hydrogel microparticles for the oral delivery of therapeutic proteins: Effects of protein size, crosslinking density, and hydrogel degradation on protein delivery.Journal of controlled release : official journal of the Controlled Release Society · 2016Article
- Micro/nanofabricated platforms for oral drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2015Review
- Stimulus-responsive hydrogels: Theory, modern advances, and applications.Materials science & engineering. R, Reports : a review journal · 2015Article
- Long-term delivery of protein therapeutics.Expert opinion on drug delivery · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
pH-Responsive hydrogels comprised of itaconic acid copolymerized with N-vinylpyrrolidone (P(IA-co-NVP)) were synthesized and tested as carriers for the oral delivery of high isoelectric point (pI) exhibiting therapeutic proteins. Swelling studies show that P(IA-co-NVP) hydrogels exhibit significantly greater and faster pH-responsive swelling than previously studied methacrylic acid-based hydrogels, achieving up to 68% greater equilibrium swelling and 10.4 times greater swelling in time-limited experiments. Using salmon calcitonin as a model high pI protein therapeutic, we show that P(IA-co-NVP) hydrogels exhibit significantly greater delivery potential than methacrylic acid-based hydrogels. Additionally, we show that utilizing a lower ionic strength solution during drug loading significantly improves drug delivery potential for high pI therapeutics. By using a 1.5mM PBS buffer rather than the standard 150 mM PBS buffer during loading, up to 83 times as much calcitonin can be delivered in neutral conditions, with up to a 9.6-fold improvement in percent release. Using P(IA-co-NVP) hydrogel microparticles and a low ionic strength loading solution, up to 48 μg calcitonin/mg hydrogel can be delivered in small intestinal conditions. Based on expected absorption in the small intestine, this is sufficient delivery potential for achieving therapeutic dosage via a single, regularly-sized pill taken daily.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.