Evidence map›Paper›PMID 24853420›Full record

ArticleCell death & disease2014

Tip30 controls differentiation of murine mammary luminal progenitor to estrogen receptor-positive luminal cell through regulating FoxA1 expression.

F Chen, A Li, S Gao, D Hollern, M Williams, F Liu, E A VanSickle, E Andrechek, C Zhang, C Yang and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

F Chen1] Department of Physiology, Michigan State University, East Lansing, MI, USA [2] Cancer Center, Southern Medical University, Guangzhou, China [3] Traditional Chinese Medicine-Integrated Hospital, Southern Medical University, Southern Medical University, Guangzhou, China.
A Li1] Department of Physiology, Michigan State University, East Lansing, MI, USA [2] Cancer Center, Southern Medical University, Guangzhou, China [3] Traditional Chinese Medicine-Integrated Hospital, Southern Medical University, Southern Medical University, Guangzhou, China.
S Gao1] Department of Physiology, Michigan State University, East Lansing, MI, USA [2] Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, USA.
D HollernDepartment of Physiology, Michigan State University, East Lansing, MI, USA.
M Williams1] Department of Physiology, Michigan State University, East Lansing, MI, USA [2] Cell and Molecular Biology Program, Michigan State University, East Lansing, MI, USA.
F Liu1] Department of Physiology, Michigan State University, East Lansing, MI, USA [2] Traditional Chinese Medicine-Integrated Hospital, Southern Medical University, Southern Medical University, Guangzhou, China.
E A VanSickleDepartment of Physiology, Michigan State University, East Lansing, MI, USA.
E AndrechekDepartment of Physiology, Michigan State University, East Lansing, MI, USA.
C ZhangDepartment of Physiology, Michigan State University, East Lansing, MI, USA.
C YangDepartment of Physiology, Michigan State University, East Lansing, MI, USA.
R Luo1] Cancer Center, Southern Medical University, Guangzhou, China [2] Traditional Chinese Medicine-Integrated Hospital, Southern Medical University, Southern Medical University, Guangzhou, China.
H Xiao1] Department of Physiology, Michigan State University, East Lansing, MI, USA [2] Cell and Molecular Biology Program, Michigan State University, East Lansing, MI, USA.
Michigan State University · USSouthern Medical University · CN

Funding

The Epigenetic Mechanism of Arsenic Lung Carcinogenesis - Role of MicroRNAsR01ES017777 · NIEHS · MICHIGAN STATE UNIVERSITY · PI YANG, CHENGFENG · 2010 to 2014
$1.7M
Dissecting Tumor Heterogeneity by Analyzing Signaling Pathway Requirements.R01CA160514 · NCI · MICHIGAN STATE UNIVERSITY · PI ANDRECHEK, ERAN ROBERT · 2012 to 2016
$1.5M
Integrative Training in the Pharmacological SciencesT32GM092715 · NIGMS · MICHIGAN STATE UNIVERSITY · PI NEUBIG, RICHARD R · 2011 to 2020
$1.5M
The Role of A Transcription Cofactor in TumorigenesisR01DK066110 · NIDDK · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI XIAO, HUA · 2004 to 2008
$1.3M
NCI NIH HHS 1R01CA160514-01A1NCI NIH HHS R01 CA160514NIDDK NIH HHS DK066110-01NIDDK NIH HHS R01 DK066110NIEHS NIH HHS 1R01ES017777-01A1NIEHS NIH HHS R01 ES017777NIGMS NIH HHS 5T32GM92715NIGMS NIH HHS T32 GM092715
6 · The paper itself

Abstract

Estrogen receptor-alpha positive (ER(+)) breast cancers comprise the majority of human breast cancers, but molecular mechanisms underlying this subtype of breast cancers remain poorly understood. Here, we show that ER(+) mammary luminal tumors arising in Tip30(-/-)MMTV-Neu mice exhibited increased enrichment of luminal progenitor gene signature. Deletion of the Tip30 gene increased proportion of mammary stem and progenitor cell populations, and raised susceptibility to ER(+) mammary luminal tumors in female Balb/c mice. Moreover, Tip30(-/-) luminal progenitors displayed increases in propensity to differentiate to mature ER(+) luminal cells and FoxA1 expression. Knockdown of FoxA1 expression in Tip30(-/-) progenitors by shRNA specific for FoxA1 reduced their differentiation toward ER(+) mature luminal cells. Taken together, our results suggest that TIP30 is a key regulator for maintaining ER(+) and ER(-)luminal pools in the mammary luminal lineage, and loss of it promotes expansion of ER(+) luminal progenitors and mature cells and ER(+) mammary tumorigenesis.

Indexed as

Cell DifferentiationAnimalsBreast NeoplasmsCarcinoma, Ductal, BreastCell LineageCell ProliferationCells, CulturedCell Transformation, NeoplasticEpithelial CellsFemaleGene Expression RegulationGene Knockdown TechniquesGenes, erbB-2Hepatocyte Nuclear Factor 3-alphaHumansMammary Glands, AnimalFoxa1 protein, mouseHepatocyte Nuclear Factor 3-alphaReceptors, EstrogenRepressor ProteinsTip30 protein, mouseTumor Suppressor Proteins

Identifiers

PMID24853420
PMCPMC4047867
OpenAlexW2022077644

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.