Evidence map›Paper›PMID 24853300›Full record

ArticleCell death and differentiation2014

Crucial role of calbindin-D28k in the pathogenesis of Alzheimer's disease mouse model.

S-Y Kook, H Jeong, M J Kang, R Park, H J Shin, S-H Han, S M Son, H Song, S H Baik, M Moon and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death and differentiation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 109 citations in OpenAlex.

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  15. Key Proteins in Rat Cerebral Cortex: Application ofMolecules (Basel, Switzerland) · 2024
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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

S-Y KookDepartment of Biochemistry and Biomedical Sciences, Seoul National University, College of Medicine, Seoul, Korea.
H JeongSchool of Interdisciplinary Bioscience and Bioengineering, Department of Chemical Engineering, POSTECH, Pohang, Korea.
M J KangDepartment of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Medicine or College of Pharmacy, Seoul National University, Seoul, Korea.
R ParkDepartment of Biochemistry and Biomedical Sciences, Seoul National University, College of Medicine, Seoul, Korea.
H J ShinDepartment of Biochemistry and Biomedical Sciences, Seoul National University, College of Medicine, Seoul, Korea.
S-H HanDepartment of Biochemistry and Biomedical Sciences, Seoul National University, College of Medicine, Seoul, Korea.
S M SonDepartment of Biochemistry and Biomedical Sciences, Seoul National University, College of Medicine, Seoul, Korea.
H SongDepartment of Biochemistry and Biomedical Sciences, Seoul National University, College of Medicine, Seoul, Korea.
S H BaikDepartment of Biochemistry and Biomedical Sciences, Seoul National University, College of Medicine, Seoul, Korea.
M MoonMolecular Neurobiology Laboratory, Department of Psychiatry and Mclean Hospital, Harvard Medical School, Belmont, MA, USA.
E C YiDepartment of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Medicine or College of Pharmacy, Seoul National University, Seoul, Korea.
D Hwang1] School of Interdisciplinary Bioscience and Bioengineering, Department of Chemical Engineering, POSTECH, Pohang, Korea [2] Department of New Biology and Center for Plant Aging Research, Institute for Basic Science, DGIST, Daegu, Korea.
I Mook-JungDepartment of Biochemistry and Biomedical Sciences, Seoul National University, College of Medicine, Seoul, Korea.
Seoul National University · KRInstitute for Basic Science · KRMcLean Hospital · USPohang University of Science and Technology · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Calbindin-D28k (CB), one of the major calcium-binding and buffering proteins, has a critical role in preventing a neuronal death as well as maintaining calcium homeostasis. Although marked reductions of CB expression have been observed in the brains of mice and humans with Alzheimer disease (AD), it is unknown whether these changes contribute to AD-related dysfunction. To determine the pathogenic importance of CB depletions in AD models, we crossed 5 familial AD mutations (5XFAD; Tg) mice with CB knock-out (CBKO) mice and generated a novel line CBKO·5XFAD (CBKOTg) mice. We first identified the change of signaling pathways and differentially expressed proteins globally by removing CB in Tg mice using mass spectrometry and antibody microarray. Immunohistochemistry showed that CBKOTg mice had significant neuronal loss in the subiculum area without changing the magnitude (number) of amyloid β-peptide (Aβ) plaques deposition and elicited significant apoptotic features and mitochondrial dysfunction compared with Tg mice. Moreover, CBKOTg mice reduced levels of phosphorylated mitogen-activated protein kinase (extracellular signal-regulated kinase) 1/2 and cAMP response element-binding protein at Ser-133 and synaptic molecules such as N-methyl-D-aspartate receptor 1 (NMDA receptor 1), NMDA receptor 2A, PSD-95 and synaptophysin in the subiculum compared with Tg mice. Importantly, this is the first experimental evidence that removal of CB from amyloid precursor protein/presenilin transgenic mice aggravates AD pathogenesis, suggesting that CB has a critical role in AD pathogenesis.

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAnimalsApoptosisCalbindin 1Cyclic AMP Response Element-Binding ProteinDisease Models, AnimalDisks Large Homolog 4 ProteinExtracellular Signal-Regulated MAP KinasesFemaleGuanylate KinasesHippocampusMembrane ProteinsMiceMice, KnockoutAmyloid beta-PeptidesAmyloid beta-Protein PrecursorCalbindin 1Cyclic AMP Response Element-Binding ProteinDisks Large Homolog 4 ProteinDlg4 protein, mouseExtracellular Signal-Regulated MAP KinasesGuanylate KinasesMembrane ProteinsReceptors, N-Methyl-D-AspartateSynaptophysinSyp protein, mouse

Identifiers

PMID24853300
PMCPMC4158683
OpenAlexW2164311084

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.