SynthesisEuropean journal of epidemiology2014
Association between physical activity and mortality in breast cancer: a meta-analysis of cohort studies.
Synthesis in European journal of epidemiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The Effects of Post-diagnosis Recreational Aerobic Exercise among Breast Cancer Survivors: A Systematic Review/Meta-Analysis.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Pooled it
- Effects of Tai Chi Chuan training on the QoL and psychological well-being in female patients with breast cancer: a systematic review of randomized controlled trials.Frontiers in oncology · 2023Pooled it
- The Practice of Physical Activity on Psychological, Mental, Physical, and Social Wellbeing for Breast-Cancer Survivors: An Umbrella Review.International journal of environmental research and public health · 2022Pooled it
- Prognostic significance of baseline skeletal muscle index and its dynamics in patients with metastatic breast cancer undergoing eribulin treatment.Breast cancer research and treatment · 2025Article
- Association between recorded physical activity and cancer progression or mortality in individuals diagnosed with cancer in South Africa.British journal of sports medicine · 2025Article
- Exercise boost after surgery improves survival in model of metastatic breast cancer.Frontiers in immunology · 2025Article
- Physical activity levels are positively related to progression-free survival and reduced adverse events in advanced ERBMC medicine · 2024Article
- Physical activity and checkpoint inhibition: association with toxicity and survival.Journal of the National Cancer Institute · 2024Article
- Changes in amount and intensity of physical activity over time in breast cancer survivors.JNCI cancer spectrum · 2023Article
- Long-term intensive endurance exercise training is associated to reduced markers of cellular senescence in the colon mucosa of older adults.npj aging · 2023Article
- Effects of a prescribed, supervised exercise programme on tumour disease progression in oncology patients undergoing anti-cancer therapy: a retrospective observational cohort study.Internal medicine journal · 2023Observational
- Application of the theory of planned behavior to understand physical activity intentions and behavior among Korean breast cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- Implementation of a Standard Care Program of Therapeutic Exercise in Metastatic Breast Cancer Patients.International journal of environmental research and public health · 2022Article
- Physical Activity and Sedentary Behavior in Relation to Cancer Survival: A Narrative Review.Cancers · 2022Review
- Dose-response association of leisure time physical activity with mortality in adults with major chronic diseases.Frontiers in nutrition · 2022Article
- Effects of 8-Week Noncontinuous Aerobic Exercise on the Levels of CCL2, CCL5, and their Respective Receptors in Female BALB/C Mice Suffering from Breast Cancer.International journal of preventive medicine · 2022Article
- Physical activity and cancer risk. Actual knowledge and possible biological mechanisms.Radiology and oncology · 2021Review
- Physical Activity Before, During, and After Chemotherapy for High-Risk Breast Cancer: Relationships With Survival.Journal of the National Cancer Institute · 2021Article
- Article
- Physical Activity and Mortality in Cancer Survivors: A Systematic Review and Meta-Analysis.JNCI cancer spectrum · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies concerning the association between physical activity (PA) and mortality in breast cancer yielded mixed results. We investigated the association by performing a meta-analysis of all available studies. Relevant studies were identified by searching PubMed and EMBASE to January 2014. We calculated the summary relative risk (RR) and 95 % confidence intervals (CIs) using random-effects models. The dose-response relationship was assessed by restricted cubic spline model and multivariate random-effect meta-regression. Sixteen cohort studies involving 42,602 patients of breast cancer were selected for meta-analysis. The analyses showed that patients who participated in any amount of PA before diagnosis had a RR of 0.82 (95 % CI 0.74-0.91) for breast cancer-specific mortality (vs. low PA). Those who participated in high PA and moderate PA before diagnosis had a RR of breast cancer-specific mortality of 0.81 (95 % CI 0.72-0.90) and 0.83 (95 % CI 0.73-0.94), respectively. Similar inverse associations of prediagnosis PA were found for all-cause mortality. Postdiagnosis PA on breast cancer-specific and all-cause mortality also showed the same results. Stratifying by body mass index (<25 vs. ≥25) or menopausal status, all the subgroups experienced benefits with PA, with a stronger mortality reduction among overweight women than normal weight women and among postmenopausal women than premenopausal women. A linear and significant dose-response association was only found for breast cancer-specific or all-cause mortality and prediagnosis PA (P for nonlinearity = 0.07 and 0.10, respectively). In conclusion, both prediagnosis and postdiagnosis PA were associated with reduced breast cancer-specific mortality and all-cause mortality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.