ArticleBritish journal of cancer2014
Long-term alcohol intake and risk of endometrial cancer in the Nurses' Health Study, 1980-2010.
Article in British journal of cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.
What it found
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Who cites it
13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Alcohol consumption and its association with cancer, cardiovascular, liver and brain diseases: a systematic review of Mendelian randomization studies.Frontiers in epidemiology · 2024Pooled it
- Influence of Alcohol Consumption on the Risk of Systemic Lupus Erythematosus Among Women in the Nurses' Health Study Cohorts.Arthritis care & research · 2017Pooled it
- Association between HSD17B1 rs605059 polymorphisms and the risk of uterine diseases: a systemic review and meta-analysis.International journal of clinical and experimental pathology · 2015Pooled it
- Causal Effects of Smoking, Alcohol, Coffee, and Tea Intake on Gynecologic Cancers: A Mendelian Randomization Study.International journal of women's health · 2025Article
- The causal effects of genetically predicted alcohol consumption on endometrial cancer risk from a Mendelian randomization study.Scientific reports · 2024Article
- Alcohol consumption and cancer incidence in women: interaction with smoking, body mass index and menopausal hormone therapy.BMC cancer · 2023Article
- Epidemiological trends and risk factors of gynecological cancers: an update.Medical oncology (Northwood, London, England) · 2023Review
- Associations of Dietary Intakes with Gynecological Cancers: Findings from a Cross-Sectional Study.Nutrients · 2022Article
- Instrumental variable estimation for a time-varying treatment and a time-to-event outcome via structural nested cumulative failure time models.BMC medical research methodology · 2021Observational
- The Effects of the Dietary and Nutrient Intake on Gynecologic Cancers.Healthcare (Basel, Switzerland) · 2019Review
- Association between Age at Menarche and Hypertension among Females in Southern China: A Cross-Sectional Study.International journal of hypertension · 2019Article
- Association between physical activity and stroke in a middle-aged and elderly Chinese population.Medicine · 2018Article
- Sedentary behavior and the risk of cardiac-cerebral vascular diseases in southern China.Medicine · 2018Observational
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundPrevious epidemiologic studies have shown inconsistent results for the association between alcohol intake and endometrial cancer risk. Most of the studies, however, assessed alcohol intake after cancer diagnosis, or measured alcohol intake at baseline only.
methodsWe prospectively examined the association between alcohol intake and endometrial cancer risk in the Nurses' Health Study with 68 067 female participants aged 34-59 years in 1980. Alcohol intake was measured several times with validated dietary questionnaires. We calculated cumulative average alcohol intake to represent long-term intakes of individual subjects. Using Cox proportional hazards models, we estimated incidence rate ratios (RRs) and 95% confidence intervals (CIs) for endometrial cancer risk after controlling for several risk factors simultaneously.
resultsWe identified a total of 794 invasive endometrial adenocarcinoma from 1980 to 2010. We found an inverse association among alcohol drinkers (multivariable RR=0.81; 95% CI: 0.68-0.96) compared with nondrinkers. Women with light alcohol intake of <5 g per day (∼half drink per day) had a 22% lower risk of endometrial cancer (multivariable RR=0.78; 95% CI: 0.66-0.94). Higher intake of alcohol, however, did not provide additional benefits against endometrial cancer: multivariable RRs for 5-14.9 g (∼1 drink), 15-29.9 g (∼2 drinks), or ≥ 30 g (≥ 2 drinks) versus 0 g per day were 0.88, 0.83, and 0.78 (95% CI: 0.49-1.25), respectively. The lower risk among drinkers (∼half drink per day) appeared to be stronger for obese women, but no significant interaction by body mass index was found.
conclusionsThis study provides prospective evidence for an inverse association between light alcohol intake (∼half drink per day) in the long term and endometrial cancer risk, but above that level no significant association was found.
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