ArticlePloS one2014
Comparison of parameter threshold combinations for diffusion tensor tractography in chronic stroke patients and healthy subjects.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 20 citations in OpenAlex.
- Sensitivity of physeal-metaphyseal tractography correlations with height velocity for fractional anisotropy threshold selection.European radiology experimental · 2026Article
- Assessment of corticospinal tract damage and cytokines response in early and late stages of acute unilateral brainstem infarction patients.Frontiers in immunology · 2024Article
- Fractional anisotropy thresholding for deterministic tractography of the roots of the brachial plexus.Scientific reports · 2021Article
- Comparative neuroanatomy: Integrating classic and modern methods to understand association fibers connecting dorsal and ventral visual cortex.Neuroscience research · 2019Review
- Diffusion-based tractography atlas of the human acoustic radiation.Scientific reports · 2019Article
- Functionally defined white matter of the macaque monkey brain reveals a dorso-ventral attention network.eLife · 2019Article
- Age-related changes in structural connectivity are improved using subject-specific thresholding.Journal of neuroscience methods · 2017Article
- Structural Alterations in the Corpus Callosum Are Associated with Suicidal Behavior in Women with Borderline Personality Disorder.Frontiers in human neuroscience · 2017Article
- Ensemble Tractography.PLoS computational biology · 2016Article
- Exploring structural connectivity alterations in CRPS: Insights from diffusion imaging and clinical correlates.Neurobiology of pain (Cambridge, Mass.)Article
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4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough quantitative evaluation of diffusion tensor imaging (DTI) data seemed to be extremely important for clinical research its application is under debate. Besides fractional anisotropy (FA) the quantitative comparison between hemispheres of the number of fibers reconstructed by means of diffusion tensor tractography (DTT) is commonly used. However, the tractography-related parameters FA, minimum tract length (LENGTH) and the angle between two contiguous tracking steps (ANGLE) are inconsistently applied. Using 18 combinations we tested for the influence of parameter thresholds on the amount of reconstructed fibers for the posterior pyramidal tract in both hemispheres in order to obtain meaningful thresholds for DTT.
resultsIn 14 chronic stroke patients with unilateral lesions of the pyramidal tract around the height of the internal capsule and considerable motor deficits a 3-way repeated-measures ANOVA showed a significant interaction between the effects of FA and ANGLE level on reconstructed fiber lateralization, F (2.9, 37.67) = 3.01, p = 0.044, and a significant main effect FA, F (1.4, 18.1) = 11.58, p = 0.001. Post-hoc pairwise comparisons showed that this interaction was completely driven by FA. In 22 right-handed healthy subjects no significant interactions or main effects could be found.
conclusionThe parameter threshold combinations with highest FA showed highest effect. ANGLE and LENGTH insofar influenced the lateralization effect when selected as liberal as possible, short LENGTH and large ANGLE thresholds. The DTT approach should be used with great care since results are highly dependent on the thresholds applied.
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