ArticlePloS one2014
Risk for femoral fractures in Parkinson's disease patients with and without severe functional impairment.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- [Inpatient treatment costs, cost-driving factors and potential reimbursement problems due to fall-related fractures in patients with Parkinson's disease].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2020Pooled it
- Risk Factors for Hip Fracture in Older Men: The Osteoporotic Fractures in Men Study (MrOS).Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2016Trial
- Peripheral nerve blocks vs selective spinal anesthesia in patients with femur fracture: a patient-, surgeon-, and assessor-blinded randomized controlled study.Journal of anesthesia, analgesia and critical care · 2025Article
- Hypnotics and injuries among older adults with Parkinson's disease: a nested case-control design.BMC geriatrics · 2023Article
- Mortality of Deep Brain Stimulation and Risk Factors in Patients With Parkinson's Disease: A National Cohort Study in Korea.Journal of Korean medical science · 2023Article
- [Treatment practice of patients with Parkinson's disease in Saxony : A secondary data-based analysis of utilization in the observation period 2011-2019].Der Nervenarzt · 2022Article
- Fractures in Parkinson's Disease: injury patterns, hospitalization, and therapeutic aspects.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2021Article
- Parkinson's disease and hip fractures: Are complications and mortality rates increased?European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2020Article
- Epidemiology of hip fractures : Systematic literature review of German data and an overview of the international literature.Zeitschrift fur Gerontologie und Geriatrie · 2019Review
- Parkinson's Disease and Symptomatic Osteoarthritis Are Independent Risk Factors of Falls in the Elderly.Clinical medicine insights. Arthritis and musculoskeletal disorders · 2019Article
- Using Medical Claims Analyses to Understand Interventions for Parkinson Patients.Journal of Parkinson's disease · 2018Review
- Comorbid Parkinson's disease, falls and fractures in the 2010 National Emergency Department Sample.Parkinsonism & related disorders · 2017Article
- Comparing the Incidence of Falls/Fractures in Parkinson's Disease Patients in the US Population.PloS one · 2016Article
- Risk of osteoporotic fractures following stroke in older persons.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundImpaired balance is a major problem in patients with idiopathic Parkinson's disease (PD) resulting in an increased risk of falls and fall-related fractures. Most studies which analyzed the risk of femoral fractures in patients with idiopathic PD were performed either in specialized centers or excluded very frail patients. The current study used a large population-based dataset in order to analyze the risk of femoral fractures in patients with idiopathic PD.
methodsData from more than 880.000 individuals aged 65 years or older and insured between 2004 and 2009 at a large German health insurance company were used for the analyses. Persons with idiopathic PD were identified by the dispensing of Parkinson-specific medication and by hospital diagnoses, if available. People without PD served as the reference group. Incident femoral fractures were obtained from hospital diagnoses. Analyses were stratified by gender and information on severe functional impairment (care need) as provided by reimbursement claims.
resultsCompared with the reference group, persons with idiopathic PD had a more than doubled risk to sustain a femoral fracture. The risk was higher in men (HR = 2.61; 95%-CI: 2.28-2.98) than in women (HR = 1.79; 95%-CI: 1.66-1.94). The increased risk was only observed in people without severe functional impairment. The sensitivity analysis using a refined definition of idiopathic PD patients yielded similar results.
conclusionThe findings confirm the increased risk of femoral fractures in patients with idiopathic PD. The relative risk is particularly high in male PD patients and in patients without severe functional impairment.
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