ArticlePLoS computational biology2014
The changing geometry of a fitness landscape along an adaptive walk.
Article in PLoS computational biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Effects of mating system and adaptedness on the evolution of fitness and mtDNA copy number in mitonuclear mismatched C. elegans.Heredity · 2025Article
- Immune pressure is key to understanding observed patterns of respiratory virus evolution in prolonged infections.Virus evolution · 2025Article
- Changing fitness effects of mutations through long-term bacterial evolution.Science (New York, N.Y.) · 2024Article
- Environmental modulation of global epistasis in a drug resistance fitness landscape.Nature communications · 2023Article
- Epistasis and pleiotropy shape biophysical protein subspaces associated with drug resistance.Physical review. E · 2023Article
- Global epistasis on fitness landscapes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Epistasis meets pleiotropy in shaping biophysical protein subspaces associated with antimicrobial resistance.bioRxiv : the preprint server for biology · 2023Article
- Getting higher on rugged landscapes: Inversion mutations open access to fitter adaptive peaks in NK fitness landscapes.PLoS computational biology · 2022Article
- Fitness of evolving bacterial populations is contingent on deep and shallow history but only shallow history creates predictable patterns.Proceedings. Biological sciences · 2022Article
- Article
- Idiosyncratic epistasis creates universals in mutational effects and evolutionary trajectories.Nature ecology & evolution · 2020Article
- Proteostasis Environment Shapes Higher-Order Epistasis Operating on Antibiotic Resistance.Genetics · 2019Article
- Patterns and Mechanisms of Diminishing Returns from Beneficial Mutations.Molecular biology and evolution · 2019Article
- Mathematical modeling of movement on fitness landscapes.BMC systems biology · 2019Article
- Article
- Cancer progression models and fitness landscapes: a many-to-many relationship.Bioinformatics (Oxford, England) · 2018Article
- Recombination and peak jumping.PloS one · 2018Article
- Effects of Beneficial Mutations in pykF Gene Vary over Time and across Replicate Populations in a Long-Term Experiment with Bacteria.Molecular biology and evolution · 2018Article
- Article
- Diminishing-returns epistasis among random beneficial mutations in a multicellular fungus.Proceedings. Biological sciences · 2016Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has recently been noted that the relative prevalence of the various kinds of epistasis varies along an adaptive walk. This has been explained as a result of mean regression in NK model fitness landscapes. Here we show that this phenomenon occurs quite generally in fitness landscapes. We propose a simple and general explanation for this phenomenon, confirming the role of mean regression. We provide support for this explanation with simulations, and discuss the empirical relevance of our findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.