Evidence map›Paper›PMID 24852207›Full record

ArticleCancer causes & control : CCC2014

Application of the Rosner-Wei risk-prediction model to estimate sexual orientation patterns in colon cancer risk in a prospective cohort of US women.

S Bryn Austin, Mathew J Pazaris, Esther K Wei, Bernard Rosner, Grace A Kennedy, Deborah Bowen, Donna Spiegelman

Open access · greenAbstract read
In one paragraph

Article in Cancer causes & control : CCC, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Accounting for Endoscopic Screening in Colorectal Cancer Risk Models.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

S Bryn AustinChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, bryn.austin@childrens.harvard.edu.
Mathew J Pazaris
Esther K Wei
Bernard Rosner
Grace A Kennedy
Deborah Bowen
Donna Spiegelman
Harvard University · USBoston Children's Hospital · USBoston University · USBrigham and Women's Hospital · USCalifornia Pacific Medical Center · US

Funding

Risk Factors for Breast Cancer in Younger NursesR01CA050385 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ELIASSEN, A. HEATHER, WILLETT, WALTER C. · 1989 to 2019
$32.3M
Premonopausal Hormone Levels and Risk of Breast CancerR01CA067262 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI HANKINSON, SUSAN E · 2002 to 2011
$11.9M
COHORT STUDY OF GENETIC SUSCEPTIBILITY TO BREAST CANCERR01CA065725 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI HUNTER, DAVID JOHN · 1996 to 2010
$4.5M
Risk Factors for Recurrent NephrolithiasisR01DK059583 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI CURHAN, GARY C. · 2002 to 2006
$2.6M
CHRONIC LIFE STRESS AND INCIDENT ASTHMA IN ADULT WOMENR01HL064108 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WRIGHT, ROSALIND J · 2000 to 2003
$1.4M
PREMENOPAUSAL HORMONE LEVELS AND RISK OF BREAST CANCERU01CA067262 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI WILLETT, WALTER C. · 1996 to 2001
$1.1M
RANDOMIZED TRIAL OF FOLATE AND COLORECTAL ADENOMAR01CA067883 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI GIOVANNUCCI, EDWARD · 1995 to 2003
$889k
NCCDPHP CDC HHS U48 DP001922NCI NIH HHS CA50385NCI NIH HHS R01 CA050385NCI NIH HHS R01 CA065725NCI NIH HHS R01 CA067262NCI NIH HHS R01 CA067883NCI NIH HHS U01 CA067262NHLBI NIH HHS HL64108NHLBI NIH HHS R01 HL064108NIDDK NIH HHS R01 DK059583
6 · The paper itself

Abstract

purposeWe examined whether lesbian and bisexual women may be at greater risk of colon cancer (CC) than heterosexual women.

methodsWorking with a large cohort of US women ages 25-64 years, we analyzed 20 years of prospective data to estimate CC incidence, based on known risk factors by applying the Rosner-Wei CC risk-prediction model. Comparing to heterosexual women, we calculated for lesbian and bisexual women the predicted 1-year incidence rate (IR) per 100,000 person-years and estimated incidence rate ratios (IRR) and 95 % confidence intervals (CI), based on each woman's comprehensive risk factor profile.

resultsAnalyses included 1,373,817 person-years of data from 66,257 women. For each sexual orientation group, mean predicted 1-year CC IR per 100,000 person-years was slightly over 12 cases for each of the sexual orientation groups. After controlling for confounders in fully adjusted models and compared with heterosexuals, no significant differences in IRR were observed for lesbians (IRR 1.01; 95 % CI 0.99, 1.04) or bisexuals (IRR 1.01; 95 % CI 0.98, 1.04).

conclusionsCC risk is similar across all sexual orientation subgroups, with all groups comparably affected. Health professionals must ensure that prevention, screening, and treatment programs are adequately reaching each of these communities.

Indexed as

Models, StatisticalAdultCohort StudiesColonic NeoplasmsFemaleHumansMiddle AgedSexual BehaviorUnited States

Identifiers

PMID24852207
PMCPMC4098762
OpenAlexW2074695557

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.