Evidence map›Paper›PMID 24851761›Full record

ArticleJournal of pediatric surgery2014

Gastrointestinal bleeding as a complication of serial transverse enteroplasty.

Jeremy G Fisher, Danielle A Stamm, Biren P Modi, Christopher Duggan, Tom Jaksic

Abstract readCase Reports
In one paragraph

Article in Journal of pediatric surgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Intestinal Failure in Children.Indian journal of pediatrics · 2016
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Jeremy G FisherDepartment of Surgery, Center for Advanced Intestinal Rehabilitation (CAIR), Boston Children's Hospital and Harvard Medical School.
Danielle A StammDepartment of Surgery, Center for Advanced Intestinal Rehabilitation (CAIR), Boston Children's Hospital and Harvard Medical School.
Biren P ModiDepartment of Surgery, Center for Advanced Intestinal Rehabilitation (CAIR), Boston Children's Hospital and Harvard Medical School.
Christopher DugganDivision of Gastroenterology and Nutrition, Center for Advanced Intestinal Rehabilitation (CAIR), Boston Children's Hospital and Harvard Medical School.
Tom JaksicDepartment of Surgery, Center for Advanced Intestinal Rehabilitation (CAIR), Boston Children's Hospital and Harvard Medical School. Electronic address: tom.jaksic@childrens.harvard.edu.
Harvard University · USBoston Children's Hospital · USCenter for Pain and the Brain · US

Funding

ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Alessio Fasano · 1994 to 2026
$31.6M
Patient-oriented Research in Pediatric Diarrheal DiseasesK24HD058795 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI DUGGAN, CHRISTOPHER P · 2010 to 2014
$956k
Patient-oriented Research in Pediatric Diarrheal DiseasesK24DK104676 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI DUGGAN, CHRISTOPHER P · 2015 to 2019
$903k
NICHD NIH HHS K24 HD058795NIDDK NIH HHS K24 DK104676NIDDK NIH HHS P30 DK040561
6 · The paper itself

Abstract

purposeSerial transverse enteroplasty (STEP) lengthens and tapers bowel in patients with intestinal failure. Evaluation and treatment of serious late gastrointestinal bleeding (GIB) in three STEP patients are described.

methodsPatients participating in an interdisciplinary intestinal rehabilitation program were reviewed to identify those who underwent STEP and had GIB requiring transfusion.

resultsOf 296 patients, 23 underwent STEP, and 3 (13%) had subsequent GIB requiring transfusion. Diagnoses were vanishing gastroschisis/atresia, malrotation/atresia, and gastroschisis.. STEP was performed at ages 3-5 months, using 5-15 stapler-firings with an increase in mean bowel length from 39 to 62 cm. GIB was diagnosed 5-30 months post-op and resulted in 1-7 transfusions per patient. Endoscopy demonstrated staple-line ulceration in two patients and eosinophilic enterocolitis in the third. All were treated with enteral antibiotics, sulfasalazine, and luminal steroids. Those with ulcers responded to bowel rest, and the patient with eosinophilic enterocolitis stabilized with luminal steroids. In all three, hemoglobin levels improved despite persistent occult bleeding.

conclusionsSignificant GIB is a potential late complication of STEP. Endoscopy identified the underlying source of GIB in all three patients. A combination of enteral antibiotics, anti-inflammatory medications, and bowel rest was effective in treating post-STEP GIB, without the need for additional bowel resection.

Indexed as

Digestive System Surgical ProceduresErythrocyte TransfusionFemaleGastrointestinal HemorrhageGastroschisisHumansInfantIntestinal AtresiaIntestinal VolvulusIntestinesJejunumPostoperative ComplicationsTime FactorsAutologous intestinal reconstruction surgery (AIRS)Gastrointestinal hemorrhageIntestinal failureSerial transverse enteroplasty (STEP)Short bowel syndrome

Identifiers

PMID24851761
PMCPMC4468065
OpenAlexW2171199190

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.