ArticleThe Korean journal of parasitology2014
Metagonimus yokogawai: a 100-kDa somatic antigen commonly reacting with other trematodes.
Article in The Korean journal of parasitology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Trematode Genomics and Proteomics.Advances in experimental medicine and biology · 2024Article
- Reliability of heterophyid antigens in heterologous protection against human schistosomiasis.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2020Article
- Fishborne zoonotic heterophyid infections: An update.Food and waterborne parasitologyReview
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5 authors.
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Abstract
This study was undertaken to characterize the properties of a 100 kDa somatic antigen from Metagonimus yokogawai. Monoclonal antibodies (mAbs) were produced against this 100 kDa antigen, and their immunoreactivity was assessed by western blot analysis with patients' sera. The mAbs against the 100 kDa antigen commonly reacted with various kinds of trematode antigens, including intestinal (Gymnophalloides seoi), lung (Paragonimus westermani), and liver flukes (Clonorchis sinensis and Fasciola hepatica). However, this mAb showed no cross-reactions with other helminth parasites, including nematodes and cestodes. To determine the topographic distribution of the 100 kDa antigen in worm sections, indirect immunoperoxidase staining was performed. A strong positive reaction was observed in the tegumental and subtegumental layers of adult M. yokogawai and C. sinensis. The results showed that the 100 kDa somatic protein of M. yokogawai is a common antigen which recognizes a target epitope present over the tegumental layer of different trematode species.
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