ReviewProceedings. Biological sciences2014
Looking beyond the hippocampus: old and new neurological targets for understanding memory disorders.
Review in Proceedings. Biological sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.
- Reevaluating the role of the hippocampus in memory: A meta-analysis of neurotoxic lesion studies in nonhuman primates.Hippocampus · 2023Pooled it
- White matter resection and verbal memory deficits after temporal lobe epilepsy surgery.Brain communications · 2026Article
- Neuroprotective effects of Simvastatin against alcohol-induced oxidative stress and neurodegeneration in the Hippocampus of adolescent mice.Metabolic brain disease · 2025Article
- First evidence of an anxiety-like behavior and its pharmacological modulation in a molluscan model organism, Lymnaea stagnalis.Translational psychiatry · 2025Article
- Retrosplenial cortex 5-HT2A receptors critically contribute to recognition memory processing.Frontiers in cellular neuroscience · 2025Article
- Cognitive outcome and its neural correlates after cardiorespiratory arrest in childhood.Developmental science · 2024Article
- Dual role of α7 nicotinic acetylcholine receptors in the retrosplenial cortex for aversive memory acquisition and retrieval.Frontiers in behavioral neuroscience · 2024Article
- The amygdala is not necessary for the familiarity aspect of recognition memory.Nature communications · 2023Article
- Korsakoff's Syndrome and Alzheimer's Disease-Commonalities and Specificities of Volumetric Brain Alterations within Papez Circuit.Journal of clinical medicine · 2023Article
- Relay and higher-order thalamic nuclei show an intertwined functional association with cortical-networks.Communications biology · 2022Article
- Memory impairment in alcohol use disorder is associated with regional frontal brain volumes.Drug and alcohol dependence · 2021Article
- T2 heterogeneity as an in vivo marker of microstructural integrity in medial temporal lobe subfields in ageing and mild cognitive impairment.NeuroImage · 2021Article
- Genetic Influences on Hippocampal Subfields: An Emerging Area of Neuroscience Research.Neurology. Genetics · 2021Review
- Thalamic, Amygdalar, and hippocampal nuclei morphology and their trajectories in first episode psychosis: A preliminary longitudinal studyPsychiatry research. Neuroimaging · 2021Article
- Anterior thalamic nuclei neurons sustain memory.Current research in neurobiology · 2021Article
- Hippocampal Subfields and Limbic White Matter Jointly Predict Learning Rate in Older Adults.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Layer 2/3 Pyramidal Neurons of the Mouse Granular Retrosplenial Cortex and Their Innervation by Cortico-Cortical Axons.Frontiers in neural circuits · 2020Article
- Dissociable Networks of the Lateral/Medial Mammillary Body in the Human Brain.Frontiers in human neuroscience · 2020Article
- Article
- The Cognitive Control of Eating and Body Weight: It's More Than What You "Think".Frontiers in psychology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Although anterograde amnesia can occur after damage in various brain sites, hippocampal dysfunction is usually seen as the ultimate cause of the failure to learn new episodic information. This assumption is supported by anatomical evidence showing direct hippocampal connections with all other sites implicated in causing anterograde amnesia. Likewise, behavioural and clinical evidence would seem to strengthen the established notion of an episodic memory system emanating from the hippocampus. There is, however, growing evidence that key, interconnected sites may also regulate the hippocampus, reflecting a more balanced, integrated network that enables learning. Recent behavioural evidence strongly suggests that medial diencephalic structures have some mnemonic functions independent of the hippocampus, which can then act upon the hippocampus. Anatomical findings now reveal that nucleus reuniens and the retrosplenial cortex provide parallel, disynaptic routes for prefrontal control of hippocampal activity. There is also growing clinical evidence that retrosplenial cortex dysfunctions contribute to both anterograde amnesia and the earliest stages of Alzheimer's disease, revealing the potential significance of this area for clinical studies. This array of findings underlines the importance of redressing the balance and the value of looking beyond the hippocampus when seeking to explain failures in learning new episodic information.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.