Trial reportThe Journal of nutrition2014
Zinc supplementation sustained normative neurodevelopment in a randomized, controlled trial of Peruvian infants aged 6-18 months.
Trial report in The Journal of nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00589264 (Zinc and Biobehavioral Development in Early Childhood), which is not on this map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Zinc and Biobehavioral Development in Early Childhood
Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Does zinc with and without iron co-supplementation have effect on motor and mental development of children? A systematic review and meta-analysis.BMC pediatrics · 2020Pooled it
- A meta-analysis of nutrition interventions on mental development of children under-two in low- and middle-income countries.Maternal & child nutrition · 2017Pooled it
- Effects of Prenatal DHA Dose on Infant Visual Attention.Developmental psychobiology · 2025Trial
- Junk food use and neurodevelopmental and growth outcomes in infants in low-resource settings.Frontiers in public health · 2024Trial
- Effectiveness of a home fortification programme with multiple micronutrients on infant and young child development: a cluster-randomised trial in rural Bihar, India.The British journal of nutrition · 2018Trial
- Trial
- Short Term Oral Zinc Supplementation among Babies with Neonatal Sepsis for Reducing Mortality and Improving Outcome - A Double-Blind Randomized Controlled Trial.Indian journal of pediatrics · 2018Trial
- The effect of daily zinc and/or multivitamin supplements on early childhood development in Tanzania: results from a randomized controlled trial.Maternal & child nutrition · 2017Trial
- Prenatal DHA supplementation and infant attention.Pediatric research · 2016Trial
- The Long Term Impact of Micronutrient Supplementation during Infancy on Cognition and Executive Function Performance in Pre-School Children.Nutrients · 2015Trial
- Executive functioning in the first 24 months: A scoping review of the A-not-B task.Psychological research · 2026Article
- Intergenerational effects of the microbiota on neurodevelopment: mechanisms and therapeutic perspectives.Acta pharmacologica Sinica · 2026Review
- Effect of probable neonatal sepsis on the development of infants in Eastern Uganda (ENON): a cohort study.BMJ paediatrics open · 2026Article
- Leveraging research in early cognitive development for application and impact.Frontiers in developmental psychology · 2026Article
- Nutrition in Early Life and Its Impact Through the Life Course.Nutrients · 2025Article
- Examining infants' visual paired comparison performance in the US and rural Malawi.Developmental science · 2024Article
- Article
- The role of zinc in the premature brain: functions, outcomes and future research perspectives.Frontiers in pediatrics · 2024Review
- Zinc supplementation for preventing mortality, morbidity, and growth failure in children aged 6 months to 12 years.The Cochrane database of systematic reviews · 2023Review
- Associations between Elemental Metabolic Dynamics and Default Mode Network Functional Connectivity Are Altered in Autism.Journal of clinical medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
A double-blind, randomized clinical trial was conducted to determine the effects of prevention of zinc deficiency on cognitive and sensorimotor development during infancy. At 6 mo of age, infants were randomly assigned to be administered a daily liquid supplement containing 10 mg/d of zinc (zinc sulfate), 10 mg/d of iron (ferrous sulfate), and 0.5 mg/d of copper (copper oxide), or an identical daily liquid supplement containing only 10 mg/d of iron and 0.5 mg/d of copper. Various controls were implemented to ensure adherence to the supplement protocol. A battery of developmental assessments was administered from 6 to 18 mo of age that included a visual habituation/recognition memory task augmented with heart rate at 6, 9, and 12 mo of age; the Bayley Scales of Infant Development, 2nd edition (BSID2) at 6, 12, and 18 mo; the A-not-B error task at 9 and 12 mo; and free-play attention tasks at 12 and 18 mo. Only infants supplemented with zinc had the normative decline in look duration from 6 to 12 mo during habituation and a normative decline in shifting between objects on free-play multiple-object attention tasks from 12 to 18 mo of age. The 2 groups did not differ on any of the psychophysiologic indices, the BSID2, or the A-not-B error task. The findings are consistent with zinc supplementation supporting a profile of normative information processing and active attentional profiles during the first 2 y of life. This trial was registered at clinicaltrials.gov as NCT00589264.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.