Evidence map›Paper›PMID 24850577›Full record

ArticleNeuroinformatics2014

Vervet MRI atlas and label map for fully automated morphometric analyses.

Joseph A Maldjian, James B Daunais, David P Friedman, Christopher T Whitlow

Open access · greenAbstract read
In one paragraph

Article in Neuroinformatics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. A nonhuman primate model of early Alzheimer's disease pathologic change: Implications for disease pathogenesis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2019
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Joseph A MaldjianAdvanced Neuroscience Imaging Research (ANSIR) Laboratory, Wake Forest School of Medicine, Winston-Salem, NC, 27157-1088, USA.
James B Daunais
David P Friedman
Christopher T Whitlow
Wake Forest University · US

Funding

Vervet Research Colony as a Biomedical ResourceP40OD010965 · OD · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Matthew Jorgensen · 2012 to 2026
$14.6M
Monkey Alcohol Tissue Research Resource (MATRR)R24AA019431 · NIAAA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Mary Lauren Benton, Verginia Carmella Cuzon Carlson · 2010 to 2026
$10.3M
VERVET RESEARCH COLONY AS A BIOMEDICAL RESOURCE: AIDSP40RR019963 · NCRR · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KAPLAN, JAY ROSS · 2005 to 2011
$6.2M
Early Stress & Alcoholism: Neurobiological AnalysisU01AA014106 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI FRIEDMAN, DAVID P · 2003 to 2011
$3.4M
iTAKL:Imaging Telemetry And Kinematic modeLing in youth football-High SchoolR01NS091602 · NINDS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MALDJIAN, JOSEPH A, STITZEL, JOEL DOUGLAS · 2016 to 2020
$3.2M
Genetic Epidemiology of Cerebrovascular Disease and Cognition in DiabetesR01NS058700 · NINDS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BOWDEN, DONALD W · 2008 to 2012
$3.0M
Cerebrovascular Disease and Cognitive Performance in African AmericansR01NS075107 · NINDS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DIVERS, JASMIN, FREEDMAN, BARRY IRA · 2011 to 2015
$2.8M
Measuring Alcohol and Stress Interactions with Structural and Perfusion MRIR01AA016748 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DAUNAIS, JAMES B · 2007 to 2009
$1.1M
MRS Interrogation of Alcohol's Neurobiochemical EffectsR03AA017710 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DAUNAIS, JAMES B · 2009 to 2010
$147k
NCRR NIH HHS P40 RR019963NIAAA NIH HHS AA014106NIAAA NIH HHS AA016748NIAAA NIH HHS AA017710NIAAA NIH HHS AA019431NIAAA NIH HHS R01 AA016748NIAAA NIH HHS R03 AA017710NIAAA NIH HHS R24 AA019431NIAAA NIH HHS U01 AA014106NIH HHS P40 OD010965NIH HHS R019963/OD010965NINDS NIH HHS NS0075107NINDS NIH HHS NS058700NINDS NIH HHS R01 NS058700NINDS NIH HHS R01 NS075107NINDS NIH HHS R01 NS091602
6 · The paper itself

Abstract

Currently available non-human primate templates typically require input of a skull-stripped brain for structural processing. This can be a manually intensive procedure, and considerably limits their utility. The purpose of this study was to create a vervet MRI population template, associated tissue probability maps (TPM), and a label atlas to facilitate true fully automated Magnetic Resonance Imaging (MRI) structural analyses for morphometric analyses. Structural MRI scans of ten vervet monkeys (Chlorocebus aethiops) scanned at three time points were used in this study. An unbiased population average template was created using a symmetric diffeomorphic registration (SyN) procedure. Skull stripping, segmentation, and label map generation were performed using the publically available rhesus INIA19 MRI template and NeuroMap label atlas. A six-class TPM and a six-layer two-class normalization template was created from the vervet segmentation for use within the Statistical Parametric Mapping (SPM) framework. Fully automated morphologic processing of all of the vervet MRI scans was then performed using the vervet TPM and vervet normalization template including skull-stripping, segmentation and normalization. The vervet template creation procedure resulted in excellent skull stripping, segmentation, and NeuroMap atlas labeling with 720 structures successfully registered. Fully automated processing was accomplished for all vervet scans, demonstrating excellent skull-stripping, segmentation, and normalization performance. We describe creation of an unbiased vervet structural MRI population template and atlas. The template includes an associated six-class TPM and DARTEL six-layer two-class normalization template for true fully automated skull-stripping, segmentation, and normalization of vervet structural T1-weighted MRI scans. We provide the most detailed vervet label atlas currently available based on the NeuroMaps atlas with 720 labels successfully registered. We additionally describe a novel method for atlas label generation that capitalizes on previous work in this area using high-dimensional highly accurate image matching procedures for inter-species morphologic normalization.

Indexed as

AlgorithmsAnimalsBrainBrain MappingChlorocebus aethiopsImage Processing, Computer-AssistedMagnetic Resonance Imaging

Identifiers

PMID24850577
PMCPMC4939823
OpenAlexW2026614276

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.