Evidence map›Paper›PMID 24850532›Full record

ArticleJAMA psychiatry2014

Risky decision making, prefrontal cortex, and mesocorticolimbic functional connectivity in methamphetamine dependence.

Milky Kohno, Angelica M Morales, Dara G Ghahremani, Gerhard Hellemann, Edythe D London

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JAMA psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed, 6 pooled it
6.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 6 syntheses or guidelines pooled it, 174 citations in OpenAlex.

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45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Milky KohnoDepartment of Psychiatry and Biobehavioral Sciences, University of California-Los Angeles.
Angelica M MoralesDepartment of Psychiatry and Biobehavioral Sciences, University of California-Los Angeles.
Dara G GhahremaniDepartment of Psychiatry and Biobehavioral Sciences, University of California-Los Angeles.
Gerhard HellemannDepartment of Psychiatry and Biobehavioral Sciences, University of California-Los Angeles.
Edythe D LondonDepartment of Psychiatry and Biobehavioral Sciences, University of California-Los Angeles2Brain Research Institute, University of California-Los Angeles3Department of Molecular and Medical Pharmacology, University of California-Los Angeles.
University of California, Los Angeles · USNeurobehavioral Systems · US

Funding

ZDV &3TC NEVIRAPINE COMBINATION THERAPY IN HIV 1 INFECTED INFANTS &M01RR000865 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WASHINGTON, ARNOLD E. · 1985 to 2011
$43.4M
UCLA Training Program in Translational Neuroscience of Drug Abuse (TNDA)T32DA024635 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LARA A. RAY, Kate M Wassum · 2008 to 2026
$6.2M
NEUROCHEMISTRY OF MODAFINIL-MA INTERACTION IN RAT BRAINP20DA022539 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LONDON, EDYTHE DANICK · 2006 to 2009
$2.9M
Neural Systems, Inhibitory Control, and Methamphetamine DependenceR01DA020726 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LONDON, EDYTHE DANICK · 2005 to 2008
$2.0M
Neural substrates of impulsive behavior in methamphetamine dependenceF31DA033117 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MORALES, ANGELICA MARIE · 2012 to 2013
$70k
Modulators of maladaptive decision-making in methamphetamine dependenceF31DA033120 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KOHNO, MILKY · 2012 to 2013
$50k
ASSOCIATION BETWEEN ILLICIT DRUG USE AND BEHAVIORAL REPERTOIRE IN ADOLESCENTSZ01DA000331 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI ANTHONY, J · 1994 to 1995
–
CSRD VA IK2 CX001790NCRR NIH HHS M01 RR000865NCRR NIH HHS M01 RR00865NIDA NIH HHS F31 DA0331-17NIDA NIH HHS F31 DA033117NIDA NIH HHS F31 DA033120NIDA NIH HHS F31 DA033120-02NIDA NIH HHS P20 DA022539NIDA NIH HHS R01 DA020726NIDA NIH HHS T32 DA024635
6 · The paper itself

Abstract

importanceVarious neuropsychiatric disorders, especially addictions, feature impairments in risky decision making; clarifying the neural mechanisms underlying this problem can inform treatment.

objectiveTo determine how methamphetamine-dependent and control participants differ in brain activation during a risky decision-making task, resting-state functional connectivity within mesolimbic and executive control circuits, and the relationships between these measures. DESIGN, SETTING, AND

participantsA case-control, functional magnetic resonance imaging study of methamphetamine-dependent and healthy comparison participants at rest and when performing the Balloon Analogue Risk Task, which involves the choice to pump a balloon or to cash out in the context of uncertain risk. Conducted at a clinical research center at an academic institution, this study involved 25 methamphetamine-dependent and 27 control participants. MAIN OUTCOMES AND MEASURES: Parametric modulation of activation in the striatum and right dorsolateral prefrontal cortex (rDLPFC; ie, the degree to which activation changed as a linear function of risk and potential reward), both indexed by pump number, and resting-state functional connectivity, measured in the whole brain with seeds in the midbrain and rDLPFC. Relationships between these outcomes were also tested.

resultsParametric modulation of cortical and striatal activation by pump number during risk taking differed with group. It was stronger in the ventral striatum but weaker in the rDLPFC in methamphetamine-dependent participants than control individuals. Methamphetamine-dependent participants also exhibited greater resting-state functional connectivity of the midbrain with the putamen, amygdala, and hippocampus (P < .05, whole brain, cluster corrected). This connectivity was negatively related to modulation of rDLPFC activation by risk level during risky decision making. In control participants, parametric modulation of rDLPFC activation by risk during decision making was positively related to resting-state functional connectivity of the rDLPFC with the striatum. CONCLUSIONS AND RELEVANCE: Maladaptive decision making by methamphetamine users may reflect circuit-level dysfunction, underlying deficits in task-based activation. Heightened resting-state connectivity within the mesocorticolimbic system, coupled with reduced prefrontal cortical connectivity, may create a bias toward reward-driven behavior over cognitive control in methamphetamine users. Interventions to improve this balance may enhance treatments for stimulant dependence and other disorders that involve maladaptive decision making.

Indexed as

AdultAmphetamine-Related DisordersAmygdalaBasal GangliaCase-Control StudiesConnectomeDecision MakingFemaleHippocampusHumansMagnetic Resonance ImagingMaleMethamphetaminePrefrontal CortexRisk-TakingMethamphetamine

Identifiers

PMID24850532
PMCPMC4119006
OpenAlexW2114523864

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.