Evidence map›Paper›PMID 24850492›Full record

ArticleNeurology2014

Effects of APOE ε4, age, and HIV on glial metabolites and cognitive deficits.

Linda Chang, Caroline Jiang, Eric Cunningham, Steven Buchthal, Vanessa Douet, Marilou Andres, Thomas Ernst

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 2 pooled it
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 2 syntheses or guidelines pooled it, 64 citations in OpenAlex.

  1. Pooled it
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  15. Neurocognitive Impairment and Associated Genetic Aspects in HIV Infection.Current topics in behavioral neurosciences · 2021
    Article
  16. Article
  17. Review
  18. Independent and Combined Effects of Nicotine or Chronic Tobacco Smoking and HIV on the Brain: A Review of Preclinical and Clinical Studies.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Linda ChangFrom the Department of Medicine, Division of Neurology, John A. Burns School of Medicine (L.C., C.J., E.C., S.B., V.D., T.E.), and Pacific Biosciences Research Center (M.A.), University of Hawai'i at Manoa, and The Queen's Medical Center, Honolulu, HI. lchang@hawaii.edu.
Caroline JiangFrom the Department of Medicine, Division of Neurology, John A. Burns School of Medicine (L.C., C.J., E.C., S.B., V.D., T.E.), and Pacific Biosciences Research Center (M.A.), University of Hawai'i at Manoa, and The Queen's Medical Center, Honolulu, HI.
Eric CunninghamFrom the Department of Medicine, Division of Neurology, John A. Burns School of Medicine (L.C., C.J., E.C., S.B., V.D., T.E.), and Pacific Biosciences Research Center (M.A.), University of Hawai'i at Manoa, and The Queen's Medical Center, Honolulu, HI.
Steven BuchthalFrom the Department of Medicine, Division of Neurology, John A. Burns School of Medicine (L.C., C.J., E.C., S.B., V.D., T.E.), and Pacific Biosciences Research Center (M.A.), University of Hawai'i at Manoa, and The Queen's Medical Center, Honolulu, HI.
Vanessa DouetFrom the Department of Medicine, Division of Neurology, John A. Burns School of Medicine (L.C., C.J., E.C., S.B., V.D., T.E.), and Pacific Biosciences Research Center (M.A.), University of Hawai'i at Manoa, and The Queen's Medical Center, Honolulu, HI.
Marilou AndresFrom the Department of Medicine, Division of Neurology, John A. Burns School of Medicine (L.C., C.J., E.C., S.B., V.D., T.E.), and Pacific Biosciences Research Center (M.A.), University of Hawai'i at Manoa, and The Queen's Medical Center, Honolulu, HI.
Thomas ErnstFrom the Department of Medicine, Division of Neurology, John A. Burns School of Medicine (L.C., C.J., E.C., S.B., V.D., T.E.), and Pacific Biosciences Research Center (M.A.), University of Hawai'i at Manoa, and The Queen's Medical Center, Honolulu, HI.
University of Hawaiʻi at Mānoa · US

Funding

RESEARCH DESIGN, BIOSTATISTICS AND RESEARCH ETHICS COREG12MD007601 · NIMHD · UNIVERSITY OF HAWAII AT MANOA · PI BERRY, MARLA J · 2012 to 2016
$13.0M
Imaging Studies in Neurotoxicity and NeurodevelopmentU54NS056883 · NINDS · UNIVERSITY OF HAWAII AT MANOA · PI CHANG, LINDA · 2007 to 2011
$8.4M
Translational Research in Neuro-AIDS and Mental HealthR25MH080661 · NIMH · JOHNS HOPKINS UNIVERSITY · PI MCARTHUR, JUSTIN CHARLES. · 2007 to 2019
$2.9M
BRAIN ACTIVATION STUDIES WITH EARLY HIV DEMENTIAR01MH061427 · NIMH · UNIVERSITY OF HAWAII AT MANOA · PI CHANG, LINDA · 1999 to 2008
$2.4M
Neuroimaging and Mentoring in Drug Abuse ResearchK24DA016170 · NIDA · UNIVERSITY OF HAWAII AT MANOA · PI CHANG, LINDA · 2003 to 2013
$1.8M
MR Techniques for Drug Abuse and HIV Brain ResearchK02DA016991 · NIDA · UNIVERSITY OF HAWAII AT MANOA · PI ERNST, THOMAS M · 2003 to 2007
$657k
NIDA NIH HHS K02-DA016991NIDA NIH HHS K24-DA016170NIMHD NIH HHS G12-MD007601-26NIMH NIH HHS 2R01-MH061427NIMH NIH HHS R25 MH080661NINDS NIH HHS U54-NS056883
6 · The paper itself

Abstract

objectiveWe aimed to evaluate the combined effects of HIV and APOE ε4 allele(s) on glial metabolite levels, and on known cognitive deficits associated with either condition, across the ages.

methodsOne hundred seventy-seven participants, primarily of white and mixed race (97 seronegative subjects: aged 44.7 ± 1.3 years, 85 [87.6%] men, 28 [28.9%] APOE ε4+; 80 HIV+ subjects: aged 47.3 ± 1.1 years, 73 [91.3%] men, 23 [28.8%] APOE ε4+), were assessed cross-sectionally for metabolite concentrations using proton magnetic resonance spectroscopy in 4 brain regions and for neuropsychological performance.

resultsFrontal white matter myo-inositol was elevated in subjects with HIV across the age span but showed age-dependent increase in seronegative subjects, especially in APOE ε4+ carriers. In contrast, only seronegative APOE ε4+ subjects showed elevated myo-inositol in parietal cortex. All APOE ε4+ subjects had lower total creatine in basal ganglia. While all HIV subjects showed greater cognitive deficits, HIV+ APOE ε4+ subjects had the poorest executive function, fluency memory, and attention/working memory. Higher myo-inositol levels were associated with poorer fine motor function across all subjects, slower speed of information processing in APOE ε4+ subjects, and worse fluency in HIV+ APOE ε4+ subjects.

conclusionsIn frontal white matter of subjects with HIV, the persistent elevation and lack of normal age-dependent increase in myo-inositol suggest that persistent glial activation attenuated the typical antagonistic pleiotropic effects of APOE ε4 on neuroinflammation. APOE ε4 negatively affects energy metabolism in brain regions rich in dopaminergic synapses. The combined effects of HIV infection and APOE ε4 may lead to greater cognitive deficits, especially in those with greater neuroinflammation. APOE ε4 allele(s) may be a useful genetic marker to identify white and mixed-race HIV subjects at risk for cognitive decline.

Indexed as

AgingCognition DisordersAdultApolipoprotein E4CholineCross-Sectional StudiesFemaleFrontal LobeHIV SeropositivityHumansImage Processing, Computer-AssistedInositolMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMaleMiddle AgedApolipoprotein E4CholineInositol

Identifiers

PMID24850492
PMCPMC4113464
OpenAlexW2066792072

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.