Evidence map›Paper›PMID 24850487›Full record

SynthesisNeurology2014

Prehospital stroke scales in urban environments: a systematic review.

Ethan S Brandler, Mohit Sharma, Richard H Sinert, Steven R Levine

Open access · bronzeAbstract readSystematic Review
In one paragraph

Synthesis in Neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 5 pooled it
10.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 5 syntheses or guidelines pooled it, 157 citations in OpenAlex.

  1. Pooled it
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  6. Trial
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  9. Article
  10. Prehospital stroke detection scales: A head-to-head comparison of 7 scales in patients with suspected stroke.International journal of stroke : official journal of the International Stroke Society · 2025
    Review
  11. Prehospital technologies for early stroke detection - A review.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025
    Review
  12. Review
  13. Article
  14. Review
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8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ethan S BrandlerFrom the Departments of Emergency Medicine (E.S.B., R.H.S., S.R.L.) and Neurology (M.S., S.R.L.), SUNY Downstate Medical Center & Kings County Hospital Center; and the Department of Internal Medicine (E.S.B.), SUNY Downstate Medical Center, Brooklyn, NY. ethan.brandler@downstate.edu.
Mohit SharmaFrom the Departments of Emergency Medicine (E.S.B., R.H.S., S.R.L.) and Neurology (M.S., S.R.L.), SUNY Downstate Medical Center & Kings County Hospital Center; and the Department of Internal Medicine (E.S.B.), SUNY Downstate Medical Center, Brooklyn, NY.
Richard H SinertFrom the Departments of Emergency Medicine (E.S.B., R.H.S., S.R.L.) and Neurology (M.S., S.R.L.), SUNY Downstate Medical Center & Kings County Hospital Center; and the Department of Internal Medicine (E.S.B.), SUNY Downstate Medical Center, Brooklyn, NY.
Steven R LevineFrom the Departments of Emergency Medicine (E.S.B., R.H.S., S.R.L.) and Neurology (M.S., S.R.L.), SUNY Downstate Medical Center & Kings County Hospital Center; and the Department of Internal Medicine (E.S.B.), SUNY Downstate Medical Center, Brooklyn, NY.
SUNY Downstate Health Sciences University · US

Funding

Field Administration of Stroke Therapy-Magnesium Trial (FAST-MAG)U01NS044364 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SAVER, JEFFREY L · 2003 to 2013
$46.4M
Interventional Management of Stroke Study (IMS III)U01NS052220 · NINDS · UNIVERSITY OF CINCINNATI · PI BRODERICK, JOSEPH PAUL · 2005 to 2012
$21.9M
THE RELATIONSHIP OF SERUM PROTEINS TO STROKE SEVERITYP50NS044283 · NINDS · UNIVERSITY OF CINCINNATI · PI JAUCH, EDWARD C · 2002 to 2012
$17.1M
Vascular Cognitive and Motor Decline: Impact of aPLR01AG040039 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI ARVANITAKIS, ZOE · 2011 to 2015
$2.9M
Stroke and aPL: Community-Based Clinicopathological StudyR01HL096944 · NHLBI · SUNY DOWNSTATE MEDICAL CENTER · PI LEVINE, STEVEN RICHARD · 2009 to 2012
$2.5M
State University of New York (SUNY) NEXT Clinical SiteU10NS077378 · NINDS · SUNY DOWNSTATE MEDICAL CENTER · PI LEVINE, STEVEN RICHARD · 2011 to 2017
$2.1M
State University of New York (SUNY) Downstate NETT Clinical Site HubU10NS080377 · NINDS · SUNY DOWNSTATE MEDICAL CENTER · PI LEVINE, STEVEN RICHARD · 2012 to 2016
$1.4M
SUNY DOWNSTATE "R TRAIN": NEUROLOGY RESEARCH EDUCATION PROGRAMR25NS079211 · NINDS · SUNY DOWNSTATE MEDICAL CENTER · PI LEVINE, STEVEN RICHARD, ROSENBAUM, DANIEL M. · 2012 to 2016
$168k
NHLBI NIH HHS 1R01HL096944NHLBI NIH HHS R01 HL096944NIA NIH HHS 1 R01 AG040039NIA NIH HHS R01 AG040039NINDS NIH HHS 1 R25 NS079211NINDS NIH HHS 1U01NS044364NINDS NIH HHS 1 U10 NS077378NINDS NIH HHS 1U10NS077378NINDS NIH HHS 1 U10 NS080377NINDS NIH HHS 1U10NS080377NINDS NIH HHS 1UO1 NS044364NINDS NIH HHS 2 P50 NS044283NINDS NIH HHS 2 U01NS052220NINDS NIH HHS P50 NS044283NINDS NIH HHS R25 NS079211NINDS NIH HHS U01 NS044364NINDS NIH HHS U01 NS052220NINDS NIH HHS U10 NS077378NINDS NIH HHS U10 NS080377
6 · The paper itself

Abstract

objectiveTo identify and compare the operating characteristics of existing prehospital stroke scales to predict true strokes in the hospital.

methodsWe searched MEDLINE, EMBASE, and CINAHL databases for articles that evaluated the performance of prehospital stroke scales. Quality of the included studies was assessed using the Quality Assessment of Diagnostic Accuracy Studies-2 tool. We abstracted the operating characteristics of published prehospital stroke scales and compared them statistically and graphically.

resultsWe retrieved 254 articles from MEDLINE, 66 articles from EMBASE, and 32 articles from CINAHL Plus database. Of these, 8 studies met all our inclusion criteria, and they studied Cincinnati Pre-Hospital Stroke Scale (CPSS), Los Angeles Pre-Hospital Stroke Screen (LAPSS), Melbourne Ambulance Stroke Screen (MASS), Medic Prehospital Assessment for Code Stroke (Med PACS), Ontario Prehospital Stroke Screening Tool (OPSS), Recognition of Stroke in the Emergency Room (ROSIER), and Face Arm Speech Test (FAST). Although the point estimates for LAPSS accuracy were better than CPSS, they had overlapping confidence intervals on the symmetric summary receiver operating characteristic curve. OPSS performed similar to LAPSS whereas MASS, Med PACS, ROSIER, and FAST had less favorable overall operating characteristics.

conclusionsPrehospital stroke scales varied in their accuracy and missed up to 30% of acute strokes in the field. Inconsistencies in performance may be due to sample size disparity, variability in stroke scale training, and divergent provider educational standards. Although LAPSS performed more consistently, visual comparison of graphical analysis revealed that LAPSS and CPSS had similar diagnostic capabilities.

Indexed as

Severity of Illness IndexDatabases, FactualHumansStrokeUrban Population

Identifiers

PMID24850487
PMCPMC4113467
OpenAlexW2080185750

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.