ReviewJournal of the American Society for Mass Spectrometry2014
Are clusters important in understanding the mechanisms in atmospheric pressure ionization? Part 1: Reagent ion generation and chemical control of ion populations.
Review in Journal of the American Society for Mass Spectrometry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed.
- Exploring Field-Induced Fragmentation of Protonated Alcohols: Mechanistic Insights and Stabilizing Ion-Solvent Clusters.Journal of the American Society for Mass Spectrometry · 2026Article
- Sensitivity vs Competing Proton Transfer Reactions: Addressing Key Parameters of Ion Chemistry in Ion Mobility Spectrometry.Journal of the American Society for Mass Spectrometry · 2025Article
- Time-Resolved Ion Mobility Spectrometry with a Stop Flow Confined Volume Reaction Region.Analytical chemistry · 2024Article
- Quantitative Distributions of Product Ions and Reaction Times with a Binary Mixture of VOCs in Ambient Pressure Chemical Ionization.Journal of the American Society for Mass Spectrometry · 2023Article
- Significance of Competitive Reactions in an Atmospheric Pressure Chemical Ionization Ion Source: Effect of Solvent.Journal of the American Society for Mass Spectrometry · 2022Article
- Observation of charged droplets from electrospray ionization (ESI) plumes in API mass spectrometers.Analytical and bioanalytical chemistry · 2021Article
- Development of an Atmospheric Pressure Chemical Ionization Interface for GC-MS.Molecules (Basel, Switzerland) · 2020Article
- Systematic Ion Source Parameter Assessment by Automated Determination of the Distribution of Ion Acceptance (DIA) Using APLI.Journal of the American Society for Mass Spectrometry · 2019Article
- Coupling of a High-Resolution Ambient Pressure Drift Tube Ion Mobility Spectrometer to a Commercial Time-of-flight Mass Spectrometer.Journal of the American Society for Mass Spectrometry · 2018Article
- Ion-neutral Clustering of Bile Acids in Electrospray Ionization Across UPLC Flow Regimes.Journal of the American Society for Mass Spectrometry · 2018Article
- Method for Continuous Monitoring of Electrospray Ion Formation.Journal of the American Society for Mass Spectrometry · 2017Article
- Effects of Solvent and Ion Source Pressure on the Analysis of Anabolic Steroids by Low Pressure Photoionization Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2017Article
- A Radical-Mediated Pathway for the Formation of [M + H](+) in Dielectric Barrier Discharge Ionization.Journal of the American Society for Mass Spectrometry · 2016Article
- A Functional Group Approach for Prediction of APPI Response of Organic Synthetic Targets.Journal of the American Society for Mass Spectrometry · 2015Article
- Regulated In Situ Generation of Molecular Ions or Protonated Molecules under Atmospheric-Pressure Helium-Plasma-Ionization Mass Spectrometric Conditions.Journal of the American Society for Mass Spectrometry · 2015Article
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is well documented since the early days of the development of atmospheric pressure ionization methods, which operate in the gas phase, that cluster ions are ubiquitous. This holds true for atmospheric pressure chemical ionization, as well as for more recent techniques, such as atmospheric pressure photoionization, direct analysis in real time, and many more. In fact, it is well established that cluster ions are the primary carriers of the net charge generated. Nevertheless, cluster ion chemistry has only been sporadically included in the numerous proposed ionization mechanisms leading to charged target analytes, which are often protonated molecules. This paper series, consisting of two parts, attempts to highlight the role of cluster ion chemistry with regard to the generation of analyte ions. In addition, the impact of the changing reaction matrix and the non-thermal collisions of ions en route from the atmospheric pressure ion source to the high vacuum analyzer region are discussed. This work addresses such issues as extent of protonation versus deuteration, the extent of analyte fragmentation, as well as highly variable ionization efficiencies, among others. In Part 1, the nature of the reagent ion generation is examined, as well as the extent of thermodynamic versus kinetic control of the resulting ion population entering the analyzer region.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.