ArticleSurgical infections2015
Multi-drug-resistant Klebsiella pneumoniae pancreatitis: a new challenge in a serious surgical infection.
Article in Surgical infections, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Biliary stents can modify the microbiota and promote the progression of pancreatic cancer.Frontiers in oncology · 2026Review
- Composition and functional profiles of gut microbiota reflect the treatment stage, severity, and etiology of acute pancreatitis.Microbiology spectrum · 2023Article
- Impact of multiple drug-resistant Gram-negative bacterial bacteraemia on infected pancreatic necrosis patients.Frontiers in cellular and infection microbiology · 2022Article
- Clinical Characteristics of Acute Pancreatitis Patients with Multidrug-Resistant Bacterial Infection.Infection and drug resistance · 2022Article
- Characteristics of and risk factors for biliary pathogen infection in patients with acute pancreatitis.BMC microbiology · 2021Article
- Predictors of mortality in acute pancreatitis complicated with multidrug-resistant Klebsiella pneumoniae infection.BMC infectious diseases · 2021Article
- Development of an Antibiotic Resistance Breaker to Resensitize Drug-ResistantFrontiers in cellular and infection microbiology · 2021Article
- Compositional and drug-resistance profiling of pathogens in patients with severe acute pancreatitis: a retrospective study.BMC gastroenterology · 2020Article
- Management of multi drug resistant endogenousIndian journal of ophthalmology · 2018Article
- Detection and genotype analysis of AmpC β-lactamase inExperimental and therapeutic medicine · 2016Article
- Enterococcus hirae Bacteremia Associated with Acute Pancreatitis and Septic Shock.Case reports in infectious diseases · 2015Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundKlebsiella pneumoniae is an important cause of nosocomial infections, but its role in severe acute pancreatitis (SAP) is not well defined. Few cases of K. pneumoniae associated SAP have been reported. Due to the emergence of extended-spectrum beta-lactamases (ESBLs) and carbapenemases, treatment of multidrug-resistant (MDR) K. pneumoniae presents a challenge. Tigecycline and colistin have gained recent attention for their broad-spectrum antimicrobial activity.
methodsWe describe a case of SAP due to K. pneumoniae bearing K. pneumoniae carbapenemase (KPC) treated successfully with colistin plus tigecycline and offer a review of similar experiences published in the literature.
resultsThe case reported herein required surgical drainage of multiple pancreatic abscesses and treatment with tigecycline and colistin. Our comparative analysis revealed a number of unique features associated with SAP due to K. pneumoniae: 1) underlying pancreatic injury, 2) multiple drug resistance determinants and virulence factors that complicate treatment, and 3) surgical debridement as a requirement for cure.
conclusionAs the prevalence of K. pneumoniae bearing KPC continues to increase in the healthcare setting, SAP caused by this MDR pathogen will become more common. Tigecycline plus colistin was a successful antibiotic regimen for the treatment of SAP due to K. pneumoniae bearing KPC.
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