ArticleJournal of neurotrauma2014
Assessment of white matter loss using bond-selective photoacoustic imaging in a rat model of contusive spinal cord injury.
Article in Journal of neurotrauma, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Advanced vibrational microscopes for life science.Nature methods · 2025Review
- Optical absorption spectra and correspondingJournal of biomedical optics · 2023Article
- Imaging increased metabolism in the spinal cord in mice after middle cerebral artery occlusion.Photoacoustics · 2023Article
- Multi-scale optoacoustic molecular imaging of brain diseases.European journal of nuclear medicine and molecular imaging · 2021Review
- Ultrasound in Traumatic Spinal Cord Injury: A Wide-Open Field.Neurosurgery · 2021Article
- Photoacoustic imaging as a highly efficient and precise imaging strategy for the evaluation of brain diseases.Quantitative imaging in medicine and surgery · 2021Review
- Photoacoustic Neuroimaging - Perspectives on a Maturing Imaging Technique and its Applications in Neuroscience.Frontiers in neuroscience · 2021Review
- Article
- Dual-comb photoacoustic spectroscopy.Nature communications · 2020Article
- All-fibre supercontinuum laser forPhotoacoustics · 2020Article
- Three-dimensional bioprinting collagen/silk fibroin scaffold combined with neural stem cells promotes nerve regeneration after spinal cord injury.Neural regeneration research · 2020Article
- Stable gastric pentadecapeptide BPC 157 can improve the healing course of spinal cord injury and lead to functional recovery in rats.Journal of orthopaedic surgery and research · 2019Article
- Testing Pathological Variation of White Matter Tract in Adult Rats after Severe Spinal Cord Injury with MRI.BioMed research international · 2018Article
- Bond-selective photoacoustic imaging by converting molecular vibration into acoustic waves.Photoacoustics · 2016Review
- Biomedical photoacoustics: fundamentals, instrumentation and perspectives on nanomedicine.International journal of nanomedicineArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
White matter (WM) loss is a critical event after spinal cord injury (SCI). Conventionally, such loss has been measured with histological and histochemical approaches, although the procedures are complex and may cause artifact. Recently, coherent Raman microscopy has been proven to be an emerging technology to study de- and remyelination of the injured spinal cord; however, limited penetration depth and small imaging field prevent it from comprehensive assessments of large areas of damaged tissues. Here, we report the use of bond-selective photoacoustic (PA) imaging with 1730-nm excitation, where the first overtone vibration of CH2 bond is located, to assess WM loss after a contusive SCI in adult rats. By employing the first overtone vibration of CH2 bond as the contrast, the mapping of the WM in an intact spinal cord was achieved in a label-free three-dimensional manner, and the physiological change of the spinal cord before and after injury was observed. Moreover, the recovery of the spinal cord from contusive injury with the treatment of a neuroprotective nanomedicine ferulic-acid-conjugated glycol chitosan (FA-GC) was also observed. Our study suggests that bond-selective PA imaging is a valuable tool to assess the progression of WM pathology after SCI as well as neuroprotective therapeutics in a label-free manner.
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Registered trials
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