ArticleObesity surgery2014
The effect of PPI use on human gut microbiota and weight loss in patients undergoing laparoscopic Roux-en-Y gastric bypass.
Article in Obesity surgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Pooled it
- Differential Changes in Gut Microbiota After Gastric Bypass and Sleeve Gastrectomy Bariatric Surgery Vary According to Diabetes Remission.Obesity surgery · 2017Trial
- Trial
- Changes in energy homeostasis, gut peptides, and gut microbiota in Emiratis with obesity after bariatric surgery.PloS one · 2025Article
- Bacteria with potential: Improving outcomes through probiotic use following Roux-en-Y gastric bypass.Clinical obesity · 2023Review
- Projection of Gut Microbiome Pre- and Post-Bariatric Surgery To Predict Surgery Outcome.mSystems · 2021Article
- Fecal metagenomics and metabolomics reveal gut microbial changes after bariatric surgery.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2020Observational
- Review
- Gut Microbiota Dysbiosis in Human Obesity: Impact of Bariatric Surgery.Current obesity reports · 2019Review
- Bariatric/Metabolic Surgery Induces Noticeable Changes of Microbiota and Their Secreting Extracellular Vesicle Composition in the Gut.Obesity surgery · 2019Article
- Roux-Y Gastric Bypass and Sleeve Gastrectomy directly change gut microbiota composition independent of surgery type.Scientific reports · 2019Article
- Impact of bariatric surgery on type 2 diabetes: contribution of inflammation and gut microbiome?Seminars in immunopathology · 2019Review
- The Impact of Bariatric Surgery on Short Term Risk of Clostridium Difficile Admissions.Obesity surgery · 2018Article
- Proton pump inhibitors as risk factor for metabolic syndrome and hepatic steatosis in coeliac disease patients on gluten-free diet.Journal of gastroenterology · 2018Observational
- Microbial Metabolic Networks at the Mucus Layer Lead to Diet-Independent Butyrate and Vitamin BmBio · 2017Article
- Impact of Long-Term Proton Pump Inhibitor Therapy on Gut Microbiota in F344 Rats: Pilot Study.Gut and liver · 2016Article
- Does Long-Term Proton Pump Inhibitor Therapy Affect the Health of Gut Microbiota?Gut and liver · 2016Article
- Losing weight for a better health: Role for the gut microbiota.Clinical nutrition experimental · 2016Article
- The gut microbiome, diet, and links to cardiometabolic and chronic disorders.Nature reviews. Nephrology · 2016Review
- Association of Proton Pump Inhibitor (PPI) Use with Energy Intake, Physical Activity, and Weight Gain.Nutrients · 2015Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Laparoscopic Roux-en-Y gastric bypass (LRYGB) achieves sustainable weight loss possibly by altering the gut microbiota. The effect of a proton pump inhibitor (PPI) on weight loss and the gut microbiota has not been explored. PPI use and the gut microbiota were assessed before and 6 months after LRYGB in eight patients. Bacterial profiles were generated by 16S ribosomal RNA (rRNA) gene sequencing. Prior to LRYGB, PPI users had a higher percent relative abundance (PRA) of Firmicutes compared to nonusers. PPI users at 6 months post-LRYGB had a higher PRA of Firmicutes [48.6 versus 35.6%, p = nonsignificant (NS)] and a trend toward significantly lower percent excess weight loss (49.3 versus 61.4%, p = 0.067) compared to nonusers. PPI use post-LRYGB may impair weight loss by modifying gut microbiota.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.