ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2014
Microvascular MRI and unsupervised clustering yields histology-resembling images in two rat models of glioma.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Radiomics and ischemic stroke research: bibliometric insights and visual trends (2004-2024).Frontiers in neurology · 2025Pooled it
- Lipophilic dye-compatible brain clearing technique allowing correlative magnetic resonance/high-resolution fluorescence imaging in rat models of glioblastoma.Scientific reports · 2020Article
- Locomotion and eating behavior changes in Yucatan minipigs after unilateral radio-induced ablation of the caudate nucleus.Scientific reports · 2019Article
- Multiparametric magnetic resonance imaging including oxygenation mapping of experimental ischaemic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
- MR Vascular Fingerprinting in Stroke and Brain Tumors Models.Scientific reports · 2016Article
- Investigating intracranial tumour growth patterns with multiparametric MRI incorporating Gd-DTPA and USPIO-enhanced imaging.NMR in biomedicine · 2016Article
- Dynamic Quantitative T1 Mapping in Orthotopic Brain Tumor Xenografts.Translational oncology · 2016Article
- Biomaterial Applications in Cell-Based Therapy in Experimental Stroke.Stem cells international · 2016Review
- A novel approach identifies the first transcriptome networks in bats: a new genetic model for vocal communication.BMC genomics · 2015Article
- Neuroimaging and neuromodulation approaches to study eating behavior and prevent and treat eating disorders and obesity.NeuroImage. Clinical · 2015Review
- Towards precision medicine: from quantitative imaging to radiomics.Journal of Zhejiang University. Science. BReview
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Authors and funding
7 authors.
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Abstract
Imaging heterogeneous cancer lesions is a real challenge. For diagnosis, histology often remains the reference, but it is widely acknowledged that biopsies are not reliable. There is thus a strong interest in establishing a link between clinical in vivo imaging and the biologic properties of tissues. In this study, we propose to construct histology-resembling images based on tissue microvascularization, a magnetic resonance imaging (MRI) accessible source of contrast. To integrate the large amount of information collected with microvascular MRI, we combined a manual delineation of a spatial region of interest with an unsupervised, model-based cluster analysis (Mclust). This approach was applied to two rat models of glioma (C6 and F98). Six MRI parameters were mapped: apparent diffusion coefficient, vessel wall permeability, cerebral blood volume fraction, cerebral blood flow, tissular oxygen saturation, and cerebral metabolic rate of oxygen. Five clusters, defined by their MRI features, were found to correspond to specific histologic features, and revealed intratumoral spatial structures. These results suggest that the presence of a cluster within a tumor can be used to assess the presence of a tissue type. In addition, the cluster composition, i.e., a signature of the intratumoral structure, could be used to characterize tumor models as histology does.
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